{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T14:54:58Z","timestamp":1740149698379,"version":"3.37.3"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,5,30]],"date-time":"2018-05-30T00:00:00Z","timestamp":1527638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Special Care in Dentistry"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>The role of genetic variations in genes related to innate response, as \u03b2\u2010defensin\u20101 (<jats:italic>DEFB1<\/jats:italic>), in the context of chronic periodontitis (CP) and diabetes mellitus type 2 (DM2), is still not clear. The present study evaluates the distribution of <jats:italic>DEFB1<\/jats:italic> single nucleotide polymorphisms (SNPs) 5\u2032\u2010untranslated (5\u2032UTR) region and its relation with the CP in DM2 individuals in northeastern Brazilians.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two hundred and eighty individuals participated in the study, being 116 DM2+CP, 95 CP, and 69 healthy individuals. Three known <jats:italic>DEFB1<\/jats:italic> functional SNPs [\u201052 G\u00a0&gt;\u00a0A (rs1799946), \u201044 C\u00a0&gt;\u00a0G (rs1800972), \u201020 G\u00a0&gt;\u00a0A (rs11362)] were genotyped with allele\u2010specific assays.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Association was found for the <jats:italic>DEFB1<\/jats:italic> \u201020 G\u00a0&gt;\u00a0A SNP. The G allele, the GA and GG genotypes were significantly (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) more frequent in the DM2+CP (59.5%, 50%, and 34.5%, respectively) and CP (61%, 44.2%, and 38.9%, respectively) than in healthy individuals (26.8%, 36.2%, and 8.7%, respectively). The GCG and ACG combinations (\u201052, \u201044, \u201020) were significantly more frequent among DM2+CP and CP than in the healthy individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results indicate that genetic variations of <jats:italic>DEFB1<\/jats:italic> gene (SNP\u201020: G allele and GA and GG genotypes) and the <jats:italic>DEFB1<\/jats:italic> 5\u2032UTR haplotypes (GCG and ACG) may be associated with a susceptibility to CP in DM2 individuals as well as CP individuals without DM2.<\/jats:p><\/jats:sec>","DOI":"10.1111\/scd.12296","type":"journal-article","created":{"date-parts":[[2018,5,30]],"date-time":"2018-05-30T13:06:21Z","timestamp":1527685581000},"page":"227-233","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Evaluation of <i>DEFB1<\/i> polymorphisms in individuals with chronic periodontitis and diabetes mellitus type 2 in a population of northeastern Brazil"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0501-8595","authenticated-orcid":false,"given":"Rayanne","family":"Soraia Aguiar de Melo Dias","sequence":"first","affiliation":[{"name":"Postgraduate Program in Dentistry Federal University of Pernambuco  Recife, PE Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2831-2722","authenticated-orcid":false,"given":"Roberto","family":"Carlos Mour\u00e3o Pinho","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Dentistry Federal University of Pernambuco  Recife, PE Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1084-5085","authenticated-orcid":false,"given":"Felipe Rodrigues de","family":"Almeida","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Dentistry Federal University of Pernambuco  Recife, PE 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