{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T02:39:34Z","timestamp":1778899174659,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Special Care in Dentistry"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to evaluate oral characteristics and comorbidities that may affect dental treatment of individuals with Williams syndrome (WS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Fifty\u2010two subjects diagnosed with WS were included in this observational study. Demographic data and medical history were compiled. Facial aspects, tooth abnormalities and oral characteristics were obtained through clinical and radiographic evaluation by a researcher\/dentist. Among 52 subjects, 25 were also evaluated for temporomandibular and occlusal disorders, caries and periodontal disease. From the 52 subjects, 23 (44.2%) were female and the average age was of 20\u00a0years old (range from 4 to 35\u00a0years old). Cognitive impairment and congenital heart disease were the most common medical disorders found in all 52 (100%) and in 41 (78.8%) subjects, respectively. Among the 52 subjects, 51 (98%) presented at least one dental developmental abnormality, with generalized diastemas (72.5%) and hypodontia (50.9%) being the most frequent ones. Angle class III malocclusion was observed in 52% (13\/25) of the subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The dentist should be aware of the medical conditions of individuals with WS and thus offer an adequate dental treatment. The high prevalence of tooth abnormalities and occlusal disorders requires an early dental treatment planning.<\/jats:p><\/jats:sec>","DOI":"10.1111\/scd.12361","type":"journal-article","created":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T17:24:20Z","timestamp":1549041860000},"page":"108-113","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Oral characteristics and medical considerations in the dental treatment of individuals with Williams syndrome"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2159-507X","authenticated-orcid":false,"given":"Talita","family":"Castro","sequence":"first","affiliation":[{"name":"Stomatology Department University of S\u00e3o Paulo School of Dentistry  S\u00e3o Paulo\u2010SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cintia","family":"de Paula Martins Santos","sequence":"additional","affiliation":[{"name":"Stomatology Department University of S\u00e3o Paulo School of Dentistry  S\u00e3o Paulo\u2010SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"de Oliveira Lira Ortega","sequence":"additional","affiliation":[{"name":"Special Care in Dentistry Division, School of Dentistry Cruzeiro do Sul University  S\u00e3o Paulo\u2010SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Gallottini","sequence":"additional","affiliation":[{"name":"Stomatology Department University of S\u00e3o Paulo School of Dentistry  S\u00e3o Paulo\u2010SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.24.6.1311"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.26.6.1235"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/088307380201700406"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0993-11"},{"key":"e_1_2_7_6_1","first-page":"214","article-title":"Genetic aspects of supravalvular aortic stenosis","volume":"13","author":"Morris CA","year":"1998","journal-title":"Curr Opin Cardiol"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1998.tb01384.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genet.34.1.297"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(75)80356-8"},{"key":"e_1_2_7_10_1","first-page":"262","article-title":"Williams syndrome\u2014oral presentation of 45 cases","volume":"16","author":"Hertzberg J","year":"1994","journal-title":"Pediatr Dent"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016350310001451"},{"key":"e_1_2_7_12_1","first-page":"7","article-title":"Medical considerations in dental treatment of patients with Williams\u2010Beuren syndrome: report of four clinical cases","volume":"21","author":"Andrade NS","year":"2015","journal-title":"Clin Lab Res Dentistry"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.11607\/jop.1151"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1515\/amb-2015-0007"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.2006.00402.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1806-83242008000100011"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adaj.2015.07.017"},{"key":"e_1_2_7_18_1","first-page":"1156","article-title":"Deletions of the elastin gene at 7q11.23 occur in approximately 90% of patients with Williams syndrome","volume":"56","author":"Nickerson E","year":"1995","journal-title":"Am J Hum Genet"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.183095"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.30265"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320370619"}],"container-title":["Special Care in Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fscd.12361","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/scd.12361","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T04:38:06Z","timestamp":1694666286000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/scd.12361"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1111\/scd.12361"],"URL":"https:\/\/doi.org\/10.1111\/scd.12361","archive":["Portico"],"relation":{},"ISSN":["0275-1879","1754-4505"],"issn-type":[{"value":"0275-1879","type":"print"},{"value":"1754-4505","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"2018-08-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}