{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T02:03:47Z","timestamp":1790474627299,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,4,16]],"date-time":"2019-04-16T00:00:00Z","timestamp":1555372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Special Care in Dentistry"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>to investigate for the first time whether the regenerative approach can be used to rehabilitate a case with regional odontodysplasia (ROD). ROD is a rare, localized developmental anomaly of the dental tissues. Moreover, we review the various treatment protocols for ROD and compare them to the suggested regenerative protocol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Report<\/jats:title><jats:p>A 22\u2010year\u2010old female patient diagnosed with ROD in the upper left quadrant was presented to our clinic. Initially, the affected teeth were extracted and three implants were inserted. A combination of autologous bone marrow mononuclear cells (BMMNCs) seeded on a collagen sponge, nanohydroxyapatite, and autologous platelet\u2010rich fibrin (PRF) was used to enhance bone regeneration in the defective area and around the inserted implants. After 9 months, bone regeneration and successful osteointegration around the inserted implants were achieved, permitting the insertion of a fourth implant. After an additional six months, a final fixed restoration was constructed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The suggested regenerative approach provides a better treatment option for ROD patients to regenerate the lost bone, rehabilitate aesthetics, and restore normal function.<\/jats:p><\/jats:sec>","DOI":"10.1111\/scd.12378","type":"journal-article","created":{"date-parts":[[2019,4,16]],"date-time":"2019-04-16T07:11:41Z","timestamp":1555398701000},"page":"330-339","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Oral rehabilitation of a case with regional odontodysplasia using a regenerative approach\u2014A case report and a review of literature"],"prefix":"10.1111","volume":"39","author":[{"given":"Mohamed Ahmed","family":"Abdel\u2010Kader","sequence":"first","affiliation":[{"name":"Department of Oro\u2010dental Genetics Medical Research Centre of Excellency National Research Centre  Cairo Egypt"},{"name":"Prosthodontic Department Faculty of Dentistry Misr International University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad Farouk","family":"Abdelazeem","sequence":"additional","affiliation":[{"name":"Department of Oro\u2010dental Genetics Medical Research Centre of Excellency National Research Centre  Cairo Egypt"},{"name":"Al\u2010Azhar Cleft Lip and Palate Treatment Center Faculty of Dental Medicine for Girls Al\u2010Azhar University  Cairo Egypt"},{"name":"Stem Cell Laboratory Centre of Excellence for Advanced Sciences National Research Centre  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5989-8650","authenticated-orcid":false,"given":"Nermeen El\u2010moataz Bellah","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Oro\u2010dental Genetics Medical Research Centre of Excellency National Research Centre  Cairo Egypt"},{"name":"Stem Cell Laboratory Centre of Excellence for Advanced Sciences National Research Centre  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmin Mohamed","family":"Khalil","sequence":"additional","affiliation":[{"name":"Department of Oro\u2010dental Genetics Medical Research Centre of Excellency National Research Centre  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa Ibrahim","family":"Mostafa","sequence":"additional","affiliation":[{"name":"Department of Oro\u2010dental Genetics Medical Research Centre of Excellency National Research Centre  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,16]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"630","article-title":"Unerupted deciduous teeth in a youth aged 15 \u00bd","volume":"56","author":"Hitchin AD","year":"1934","journal-title":"Br. 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