{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T14:46:11Z","timestamp":1776782771220,"version":"3.51.2"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Special Care in Dentistry"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/aim<\/jats:title><jats:p>Osteopetrosis is an inherited disease characterized by increased bone density. Its genetic variability results in various phenotype expressions, whereas clinically are classified in three types: malignant infantile, intermediate and adult. The various oral manifestations of the disease give a crucial role to the pediatric dentists in diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>A 7\u2010year\u2010old girl with persistent swelling on right cheek visited a pedodontic clinic. After extra\u2010 and intra\u2010oral examination\/findings, the patient was referred for further investigation concerning a possible general pathological background. An extraction, included in the initial dental treatment plan, led to the diagnosis of osteopetrosis. Various medical examinations co\u2010led to the diagnosis of osteopetrosis but without genetic identification. Extractions of carious teeth, under general anesthesia, and full cover or sealants, on chair, of unaffected teeth were conducted respectively to minimize the microbial load and to prevent from osteomyelitis relapse and new caries. Two more general anesthesia sessions took place due to relapse of lower jaw osteomyelitis. Follow\u2010up was conducted every 3 months for 2 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Osteopetrosis\u2019 diagnosis can be triggered by its oral manifestations (rampant caries, osteonecrosis, enamel defects, malformed roots\/crowns, missing teeth), for which the pediatric dentist could be the first observer. Management of these patients needs multidisciplinary approach and follow\u2010up appointments should be very frequent.<\/jats:p><\/jats:sec>","DOI":"10.1111\/scd.12427","type":"journal-article","created":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T11:03:37Z","timestamp":1572606217000},"page":"113-120","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["When a pedodontic examination leads to the diagnosis of osteopetrosis: A case report"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6220-5007","authenticated-orcid":false,"given":"Eirini","family":"Athanasiadou","sequence":"first","affiliation":[{"name":"Department of Pediatric Dentistry, School of Dentistry Aristotle University of Thessaloniki  Central Macedonia Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Vlachou","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, School of Dentistry Aristotle University of Thessaloniki  Central Macedonia Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Apostolina","family":"Theocharidou","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, School of Dentistry Aristotle University of Thessaloniki  Central Macedonia Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioannis","family":"Tilaveridis","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, School of Dentistry Aristotle University of Thessaloniki  Central Macedonia Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Efthimia","family":"Vargiami","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology, A\u2019 Pediatric Clinic Aristotle University of Thessaloniki  Central Macedonia Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos","family":"Antoniadis","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, School of Dentistry Aristotle University of Thessaloniki  Central Macedonia Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos","family":"Arapostathis","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, School of Dentistry Aristotle University of Thessaloniki  Central Macedonia Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,11]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"365","article-title":"R\u00f6ntgenbilder einer seltenen Knochenerkrankung","volume":"5","author":"Albers\u2010Sch\u00f6nberg HE","year":"1904","journal-title":"M\u00fcnchener Medizinische Wochenschrift"},{"key":"e_1_2_8_3_1","first-page":"755","article-title":"Osteopetrosis: 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