{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T00:41:19Z","timestamp":1775868079169,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T00:00:00Z","timestamp":1605484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Special Care in Dentistry"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study investigates the influence of insulin on pulp tissue healing after pulp capping in diabetic dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Diabetes mellitus was induced in four dogs, and their blood glucose levels were adjusted by insulin to normoglycemic level in two dogs (normoglycemic group) and to hyperglycemic level in two dogs (hyperglycemic group). Class V buccal cavities were performed in 15 teeth in each diabetic dog and two normal dogs (control group). The three groups (30 teeth each) were divided according to the capping materials into three subgroups (10 teeth each) including: subgroup A \u2010 mineral trioxide aggregate (MTA), subgroup B \u2010 bioaggregate (BA), and subgroup C \u2010 calcium hydroxide (Ca(OH)<jats:sub>2<\/jats:sub>). Each subgroup was divided into two subdivisions according to the evaluation period, subdivision 1: 1 month and subdivision 2: 2 months. Qualitative and quantitative evaluations of the inflammation and dentine bridge formation were assessed histologically.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The hyperglycemic diabetic group exhibited significant higher inflammatory cell count and scores and lower dentine bridge thickness than those of the normoglycemic diabetic and control groups (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a0.05). There were no significant differences in these parameters between the normoglycemic diabetic and control groups (<jats:italic>P\u00a0<\/jats:italic>&gt;\u00a0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Insulin has favourable effects on the pulp tissue healing after pulp capping in diabetic dogs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/scd.12545","type":"journal-article","created":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T17:25:19Z","timestamp":1605547519000},"page":"49-59","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Influence of insulin on the healing of exposed dental pulp after pulp capping: An experimental study in a dog model"],"prefix":"10.1111","volume":"41","author":[{"given":"Mokhtar A.","family":"Al\u2010Anesi","sequence":"first","affiliation":[{"name":"Department of Endodontic Faculty of Dentistry Thamar University Dhamar Yemen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5466-2016","authenticated-orcid":false,"given":"Ashraf M.","family":"Abu\u2010Seida","sequence":"additional","affiliation":[{"name":"Department of Surgery Anesthesiology and Radiology Faculty of Veterinary Medicine Cairo University Giza Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salma H.","family":"El Ashry","sequence":"additional","affiliation":[{"name":"Department of Endodontic Faculty of Dentistry Ain Shams University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abeer H.","family":"Mahran","sequence":"additional","affiliation":[{"name":"Department of Endodontic Faculty of Dentistry Ain Shams University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ehab S.","family":"Abd\u2010Elhamid","sequence":"additional","affiliation":[{"name":"Department of Endodontic Faculty of Dentistry Ain Shams University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,11,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004770-200311000-00011"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sdentj.2020.02.001"},{"key":"e_1_2_8_4_1","first-page":"685","article-title":"Influence of addition of osteogenic supplements to mineral trioxide aggregate on the gene expression level of odontoblastic markers following pulp capping in dogs","volume":"86","author":"El Ashry SH","year":"2016","journal-title":"Vet Arhiv"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etp.2016.12.006"},{"key":"e_1_2_8_6_1","first-page":"278","article-title":"Physical evaluation of a new pulp capping material developed from Portland cement","volume":"8","author":"Negm AM","year":"2016","journal-title":"J Clin Exp 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