{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:00:40Z","timestamp":1747188040526,"version":"3.40.5"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,27]],"date-time":"2020-12-27T00:00:00Z","timestamp":1609027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Special Care in Dentistry"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Paroxysmal nocturnal hemoglobinuria (PNH) is a hematological disorder that affects hematopoietic stem cells. An association with other hematological diseases, such as hemolytic anemia and neutropenia, is observed with a high occurrence of aplastic anemia. The aim of the present study is to report a case of dental infection in a patient with PNH exhibiting exuberant gingival involvement. A 45\u2010year\u2010old male patient sought the Federal University of Ceara reporting severe toothache associated with tooth 24. Clinical examination revealed that the tooth was associated with an apparent fistula and a yellowish lesion with smooth surface located in the palate. The patient had interrupted the medication to control PNH. Blood transfusion was requested due to deficient hematological parameters. Tooth extraction and excisional biopsy were performed under antibiotic coverage. In the postoperative period, low\u2010level laser therapy (LLLT) was performed. Histopathological examination revealed connective tissue showing extensive necrotic areas, accumulation of basophilic material, numerous cyst\u2010like cavities, and degenerated cells. Histopathological findings were compatible with the initial clinical diagnosis of gingival necrosis. The patient evolved with febrile neutropenia, requiring hospitalization for 1 month. Improvement in the overall health was observed after the administration of antibiotics, eculizumab, and weekly LLLT at the biopsy site.<\/jats:p>","DOI":"10.1111\/scd.12552","type":"journal-article","created":{"date-parts":[[2020,12,27]],"date-time":"2020-12-27T19:12:37Z","timestamp":1609096357000},"page":"277-281","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dental infection associated with exuberant gingival necrosis in a patient with paroxysmal nocturnal hemoglobinuria: A case report"],"prefix":"10.1111","volume":"41","author":[{"given":"Iury da Silva","family":"Ximenes","sequence":"first","affiliation":[{"name":"Division of Oral Pathology, Faculty of Pharmacy, Dentistry and Nursing Federal University of Cear\u00e1  Fortaleza Cear\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osias Vieira de Oliveira","family":"Filho","sequence":"additional","affiliation":[{"name":"Division of Oral Pathology, Faculty of Pharmacy, Dentistry and Nursing Federal University of Cear\u00e1  Fortaleza Cear\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e1ssia Emanuella N\u00f3brega","family":"Malta","sequence":"additional","affiliation":[{"name":"Division of Oral Pathology, Faculty of Pharmacy, Dentistry and Nursing Federal University of Cear\u00e1  Fortaleza Cear\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thinalli Sousa","family":"Dantas","sequence":"additional","affiliation":[{"name":"Division of Oral Pathology, Faculty of Pharmacy, Dentistry and Nursing Federal University of Cear\u00e1  Fortaleza Cear\u00e1 Brazil"},{"name":"Department of Dentistry Unichristus  Fortaleza Cear\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Paula Negreiros Nunes","family":"Alves","sequence":"additional","affiliation":[{"name":"Division of Oral Pathology, Faculty of Pharmacy, Dentistry and 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