{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T12:14:10Z","timestamp":1785154450389,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T00:00:00Z","timestamp":1611187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Special Care in Dentistry"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>It was analyzed the efficacy of mouthwash and spray containing essential oil (EO) of<jats:italic>Cinnamomum zeylanicum<\/jats:italic>Blume for the treatment of oral candidiasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>A randomized, controlled, and blinded clinical trial was conducted with 36 individuals (probabilistic sample) with oral candidiasis who were divided into two treatment groups:<jats:italic>C. zeylanicum<\/jats:italic>(0.5\u00a0mg\/mL), n\u00a0=\u00a018; nystatin (100,000IU\/mL), n\u00a0=\u00a018. The efficacy of the products was evaluated by two parameters: (a) clinical evolution recorded by calibrated examiners (Kappa\u00a0=\u00a00.822) according to Newton's classification and (b) reduction of colony\u2010forming units\/mL. Mycological and clinical parameters were analyzed before and at 15 days after treatment. Clinical examination of the mucosa showed that<jats:italic>C. zeylanicum<\/jats:italic>(p\u00a0&lt;\u00a00.0339) and nystatin (p\u00a0&lt;\u00a0.0139) had efficacy, resulting in a reduction of signs and symptoms (<jats:styled-content>Mann\u2010Whitney test)<\/jats:styled-content>. Mycological analysis showed that<jats:italic>C. zeylanicum<\/jats:italic>caused a reduction of 61% and 33% of<jats:italic>Candida<\/jats:italic>spp., isolates oral mucosa and dentures, respectively.<jats:italic>Candida tropicalis<\/jats:italic>strains were eliminated after<jats:italic>C. zeylanicum<\/jats:italic>, in both sites. The participants reported a pleasant taste and few product\u2010related complaints.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:italic>C. zeylanicum<\/jats:italic>EO and nystatin exhibited clinical efficacy, according to the Newton classification, and reducing in<jats:italic>Candida<\/jats:italic>spp. The clinical trial has been registered (Registration number: NBR\u201333s6\u00a0\u00d7\u00a05, ensaiosclinicos.gov.br).<\/jats:p><\/jats:sec>","DOI":"10.1111\/scd.12570","type":"journal-article","created":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T18:59:57Z","timestamp":1611255597000},"page":"349-357","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Efficacy of essential oil of cinnamon for the treatment of oral candidiasis: A randomized trial"],"prefix":"10.1111","volume":"41","author":[{"given":"Maria Rejane Cruz","family":"de Ara\u00fajo","sequence":"first","affiliation":[{"name":"Departament of Clinical and Social Dentistry Federal University of Para\u00edba Jo\u00e3o Pessoa Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panmella Pereira","family":"Maciel","sequence":"additional","affiliation":[{"name":"Departament of Clinical and Social Dentistry Federal University of Para\u00edba Jo\u00e3o Pessoa Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00facio Roberto Can\u00e7ado","family":"Castellano","sequence":"additional","affiliation":[{"name":"Technical Health School Federal University of Para\u00edba Jo\u00e3o Pessoa Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Rog\u00e9rio Ferreti","family":"Bonan","sequence":"additional","affiliation":[{"name":"Departament of Clinical and Social Dentistry Federal University of Para\u00edba Jo\u00e3o Pessoa Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle da N\u00f3brega","family":"Alves","sequence":"additional","affiliation":[{"name":"Departament of Clinical and Social Dentistry Federal University of Para\u00edba Jo\u00e3o Pessoa Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Cl\u00e1udia Dantas","family":"de Medeiros","sequence":"additional","affiliation":[{"name":"Departament of Pharmaceutical Sciences State University of Para\u00edba Campina Grande Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Dias","family":"de Castro","sequence":"additional","affiliation":[{"name":"Departament of Clinical and Social Dentistry Federal University of Para\u00edba Jo\u00e3o Pessoa Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.12816\/0003318"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-029X.141325"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jopr.12551"},{"issue":"2","key":"e_1_2_9_5_1","first-page":"54","article-title":"Candida albicans importance to denture wearers. 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