{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T17:58:51Z","timestamp":1781373531160,"version":"3.54.1"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T00:00:00Z","timestamp":1612742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Special Care in Dentistry"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>There is a deficiency in the data concerning the clinical forms of methotrexate\u2010induced oral ulcers. This study was conducted to stratify clinical forms of methotrexate\u2010induced oral ulcers in rheumatoid arthritis patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included rheumatoid arthritis patients receiving methotrexate as monotherapy. All eligible patients were subjected to thorough clinical examination and full history to identify oral events. Drug history, dose, and duration of MTX were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 794 rheumatoid arthritis patients, mean methotrexate dose and duration were 14.3 mg\/week and 5.2 years, respectively. Oral ulcers were detected in 6.2% of the patients and 30% of the patients reported previous oral ulcers. Among the detected oral ulcers, 44.9% manifested as deep irregular ulcers, 30.6% presented as aphthous\u2010like ulcers, 14.3% were diffuse mucositis, and 10.2% appeared as lichenoid reaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Methotrexate\u2010induced oral ulceration could be localized or generalized. Localized forms were more noticed than generalized forms. Higher doses and longer durations of methotrexate were detected among patients with generalized oral ulcers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/scd.12575","type":"journal-article","created":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T17:08:26Z","timestamp":1612976906000},"page":"367-371","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Stratification of methotrexate\u2010induced oral ulcers in rheumatoid arthritis patients"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0134-1582","authenticated-orcid":false,"given":"Eman","family":"Magdy","sequence":"first","affiliation":[{"name":"Department of Oral Medicine and Periodontology Faculty of Dentistry Beni\u2010suef University  Beni\u2010suef Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3794-2491","authenticated-orcid":false,"given":"Shereen","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Periodontology Faculty of Dentistry Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdsr.2013.12.001"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2014.09.009"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2008.02637.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2004.08.020"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-018-0016-9"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27584"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-210602"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.4811972"},{"issue":"1","key":"e_1_2_9_10_1","first-page":"S5","article-title":"Mechanisms of action of methotrexate","volume":"71","author":"Chan ES","year":"2013","journal-title":"Bull Hosp Jt Dis"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.14476\/jomp.2015.40.2.82"},{"issue":"6","key":"e_1_2_9_12_1","article-title":"Methotrexate for treating rheumatoid arthritis","volume":"2014","author":"Lopez\u2010Olivo MA","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.13339"},{"issue":"2","key":"e_1_2_9_14_1","first-page":"101","article-title":"Adverse effects of low dose methotrexate in rheumatoid arthritis patients","volume":"22","author":"Gilani ST","year":"2012","journal-title":"J Coll Physicians Surg Pak"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.130738"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40360-019-0316-8"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02114393"},{"issue":"8","key":"e_1_2_9_18_1","first-page":"909","article-title":"Adverse effects of low dose methotrexate in rheumatoid arthritis patients. 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