{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T14:53:01Z","timestamp":1781967181406,"version":"3.54.5"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T00:00:00Z","timestamp":1616544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Special Care in Dentistry"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Denosumab is a nonsurgical treatment option for central giant cell granulomas (CGCG), especially in aggressive lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case report<\/jats:title><jats:p>We describe a 9\u2010year\u2010old girl with an aggressive maxillary CGCG successfully treated with denosumab, avoiding a mutilating surgery after intralesional corticosteroid injections failed, and the lesion continued to rapidly grow. During denosumab treatment, she developed a self\u2010limiting area of osteonecrosis in the maxillary alveolar bone, which rapidly resolved after antibiotic therapy. Six months after denosumab discontinuation, a maxillary surgical recontour was performed. Two weeks after surgery, the patient presented vomiting, pallor, dehydration, but no fever. Blood tests revealed severe hypercalcemia and acute renal dysfunction. After discarding thyroid, parathyroid, and adrenal alterations, a diagnosis of severe rebound hypercalcemia after denosumab treatment was made. Treatment consisted of hyperhydration, calcium pamidronate, and methylprednisolone, restoring calcium levels to normal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>After 2 years of follow\u2010up, she remains on orthodontic treatment, with no recurrences or other episodes of hypercalcemia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/scd.12588","type":"journal-article","created":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T15:06:29Z","timestamp":1616598389000},"page":"519-525","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Successful denosumab treatment for central giant cell granuloma in a 9\u2010year\u2010old child"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8036-0705","authenticated-orcid":false,"given":"Bruno Augusto Linhares Almeida","family":"Mariz","sequence":"first","affiliation":[{"name":"Oral Diagnosis Department Piracicaba Dental School University of Campinas  Piracicaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2535-2606","authenticated-orcid":false,"given":"C\u00e9sar Augusto","family":"Migliorati","sequence":"additional","affiliation":[{"name":"College of Dentistry University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3372-1536","authenticated-orcid":false,"given":"Fabio de Abreu","family":"Alves","sequence":"additional","affiliation":[{"name":"Oral Medicine Department AC Camargo Cancer Center  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana de Moraes","family":"Penteado","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology AC Camargo Cancer Center  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Filho","given":"Nevi\u00e7olino Pereira","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology AC Camargo Cancer Center  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2040-6617","authenticated-orcid":false,"given":"Alan Roger","family":"Santos\u2010Silva","sequence":"additional","affiliation":[{"name":"Oral Diagnosis Department Piracicaba Dental School University of Campinas  Piracicaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0070-0640","authenticated-orcid":false,"given":"Andr\u00e9 Caroli","family":"Rocha","sequence":"additional","affiliation":[{"name":"Oral Medicine Department AC Camargo Cancer Center  S\u00e3o Paulo Brazil"},{"name":"Clinics Hospital of the Medical School of the University of S\u00e3o Paulo  S\u00e3o Paulo 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