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The genomic DNA was extracted from blood according to the Salting Out method followed by a quantification using the NanoDrop spectrophotometer. The \u2013308G\/A <jats:italic>TNF\u2010\u03b1<\/jats:italic> polymorphism analysis was performed by the polymerase chain reaction\u2010restriction fragment\u00a0length polymorphism technique, the determination of \u2013174G\/C <jats:italic>IL\u20106<\/jats:italic> polymorphism was performed by polymerase chain reaction, and the evaluation of the \u20131082A\/G <jats:italic>IL\u201010<\/jats:italic> polymorphism was carried out by polymerase chain reaction\u2010 allele\u2010specific\u00a0amplification. Data were analyzed using the BioEstat 5.3 software.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The \u2013308G\/A <jats:italic>TNF\u2010\u03b1<\/jats:italic> polymorphism showed a significant difference when genotypes of cases with chronic temporomandibular disorder pain and controls were compared (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.025). There was a lack of association regarding the \u2013174G\/C <jats:italic>IL\u20106<\/jats:italic> polymorphism (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.286) however, a positive association between the \u20131082A\/G <jats:italic>IL\u201010<\/jats:italic> polymorphism with chronic temporomandibular disorder was observed (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.020).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The analyzed data of elderly subjects support the possible involvement of the GA genotype of the \u2013308G\/A <jats:italic>TNF\u2010\u03b1<\/jats:italic> and the AA genotype of the \u20131082A\/G <jats:italic>IL\u201010<\/jats:italic> polymorphisms in the pathogenesis of chronic temporomandibular disorder pain.<\/jats:p><\/jats:sec>","DOI":"10.1111\/scd.12757","type":"journal-article","created":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T21:49:25Z","timestamp":1658180965000},"page":"144-151","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Genetic polymorphisms of <i>TNF\u2010\u03b1, IL\u20106<\/i>, and <i>IL\u201010<\/i> in female elderly patients with chronic temporomandibular disorder pain"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6689-5466","authenticated-orcid":false,"given":"Camilla Porto","family":"Campello","sequence":"first","affiliation":[{"name":"MSc in Speech Sciences, PhD in Biotechnology in Health at Northeast Biotechnology Network\u2010 RENORBIO\/UFRPE, Laboratory of Molecular Biology Oswaldo Cruz University Hospital  Recife Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elker Lene 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