{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T01:03:30Z","timestamp":1772931810193,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T00:00:00Z","timestamp":1660608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Special Care in Dentistry"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine the factors associated with public hospital dentists\u2019 awareness of <jats:italic>HLA\u2010B*15:02<\/jats:italic> screening in trigeminal neuralgia (TN) and the national gene screening policy in Thailand.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cross\u2010sectional study. A validated questionnaire was distributed to public hospital dentists with at least 1 year of practice in Southern Thailand (<jats:italic>n<\/jats:italic> =\u00a0760) to assess their knowledge of TN, carbamazepine (CBZ) use, awareness of <jats:italic>HLA\u2010B*15:02<\/jats:italic> screening, and the gene screening policy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 385 dentists participated (50.7% response rate); 81.3% of respondents were aware of <jats:italic>HLA\u2010B*15:02<\/jats:italic> screening. However, 18.7% of dentists were not aware of the importance of gene testing. Furthermore, dentists who were aware of gene screening had significantly better knowledge of TN diagnosis and CBZ use than \u201cunaware\u201d dentists. Awareness of <jats:italic>HLA\u2010B*15:02<\/jats:italic> screening was also significantly associated with dental specialty. Moreover, 80.5% of respondents were not aware of the gene screening policy. The primary problems related to the policy were its inefficient publication, poor implementation, and lack of clinical practice guidelines (CPGs) to encourage dentists to follow the policy and prescribe gene tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>While most hospital dentists were aware of the necessity of <jats:italic>HLA\u2010B*15:02<\/jats:italic> screening prior to prescribing CBZ in TN, the majority were unaware of the national gene screening policy. Dental specialty and knowledge were associated with awareness of <jats:italic>HLA\u2010B*15:02<\/jats:italic> screening.<\/jats:p><\/jats:sec>","DOI":"10.1111\/scd.12768","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T02:45:21Z","timestamp":1660704321000},"page":"286-293","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Awareness of <i>HLA\u2010B* 15:02<\/i> screening in trigeminal neuralgia and the gene screening policy among dentists in Southern Thailand"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3437-0539","authenticated-orcid":false,"given":"Jirayu","family":"Saepoo","sequence":"first","affiliation":[{"name":"Section of Oral Medicine, Department of Oral Diagnostic Sciences, Faculty of Dentistry Prince of Songkla University  Hatyai Songkhla Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7197-2750","authenticated-orcid":false,"given":"Kanokporn","family":"Pangsomboon","sequence":"additional","affiliation":[{"name":"Section of Oral Medicine, Department of Oral Diagnostic Sciences, Faculty of Dentistry Prince of Songkla University  Hatyai Songkhla Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8962-7162","authenticated-orcid":false,"given":"Sukanya","family":"Tianviwat","sequence":"additional","affiliation":[{"name":"Department of Preventive Dentistry, Faculty of Dentistry Prince of Songkla University  Hatyai Songkhla Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102416687280"},{"key":"e_1_2_8_3_1","first-page":"327","volume-title":"Orofacial Pain: Guidelines for Assessment, Diagnosis and Management","author":"Leeuw RD","year":"2018"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h1238"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417738202"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2001.111189"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756285609359317"},{"issue":"5","key":"e_1_2_8_8_1","first-page":"467","article-title":"Prevalence and mortality rate of severe cutaneous adverse reactions at Siriraj Hospital","volume":"54","author":"Limkobpaiboon S","year":"2010","journal-title":"Chula Med J"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2010.04745.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1009717"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12217"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2010.02533.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/2780272"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00078"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-013-9777-9"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2010.12.054"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12325"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00527"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001034"},{"key":"e_1_2_8_20_1","unstructured":"Ratchakitcha The secretariat of the cabinet. Pharmacogenic screening forHLAB*1502genotype testing prior to initiation of carbamazepine in any therapy [Internet]. Thailand: Ministry of Public Health; 2018 [updated 2019; cited 2019 Dec 29]. 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