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Methimazole is a thionamide derivative considered among the first\u2010choice treatment options for hyperthyroidism. However, it may cause serious side effects such as neutropenia or agranulocytosis, which, although rare, can lead to death. The clinical manifestations of this complication range from fever, ulcerations in the oral and pharyngeal mucosa, tonsillitis, and lymphadenopathy to hemorrhagic necrosis and septicemia. This report describes the case of a patient with generalized gingival necrosis that was related to the use of methimazole for the treatment of hyperthyroidism.<\/jats:p>","DOI":"10.1111\/scd.12771","type":"journal-article","created":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T02:29:57Z","timestamp":1660876197000},"page":"475-480","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Generalized gingival necrosis in a patient under methimazole use"],"prefix":"10.1111","volume":"43","author":[{"given":"Rita Fabiane Teixeira","family":"Gomes","sequence":"first","affiliation":[{"name":"Department of Oral Pathology, School of Dentistry Federal University of Rio Grande do Sul  Porto Alegre RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"Klein","sequence":"additional","affiliation":[{"name":"Outpatient Clinic of Stomatology Pontifical Catholic University of Rio Grande do Sul  Porto Alegre RS Brazil Egress"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edilson Fernando","family":"Castelo","sequence":"additional","affiliation":[{"name":"Multi\u2010professional Residency in Health University of Santa Cruz do Sul  Santa Cruz do Sul RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vin\u00edcius Coelho","family":"Carrard","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, School of Dentistry Federal University of Rio Grande do Sul  Porto Alegre RS Brazil"},{"name":"Oral Medicine Unit, Otorhinolaryngology Service Federal University of Rio Grande do Sul  Porto Alegre RS Brazi"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,18]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2020-235536"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina56060290"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000490384"},{"key":"e_1_2_5_5_1","first-page":"210","article-title":"Thionamide associated agranulocytosis: low incidence with low doses of methimazole","volume":"4","author":"Bahrami A","year":"2006","journal-title":"Int J Endocrinol Metab"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0365-05962013000200021"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2016.0229"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-2569"},{"issue":"3","key":"e_1_2_5_9_1","first-page":"1","article-title":"Necrotizing ulcerative gingivitis in a patient with 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