{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T16:41:58Z","timestamp":1764175318284},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,9,18]],"date-time":"2022-09-18T00:00:00Z","timestamp":1663459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Special Care in Dentistry"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Noonan syndrome (NS) is a clinically and genetically heterogeneous condition characterized by distinctive facial features, short stature, and congenital heart defects. The oral manifestations have not been sufficiently described. In an attempt to enrich our understanding regarding the oral manifestations, the aim of the current study was to present the clinical, radiographic, and microbiological findings of eleven subjects with NS syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>A complete intraoral clinical evaluation, a radiographic analysis using panoramic and cephalometric x\u2010rays, and a supra\u2010 and sub\u2010gingival microbiological profiling of 20 periodontal and cariogenic microbiota using the checkerboard DNA\u2010DNA hybridization technique were performed in a series of 11 NS individuals. Compared to previous reports very few dental findings were present. Gingivitis and carious lesions were present in all subjects and could be related to poor oral hygiene. High\u2010arched palate and malocclusions such as crossbite, open\u2010bite, and deep\u2010bite were very common findings but without a specific pattern. Two findings that have not been reported before included the different shapes of the condyles and the irregular shape of the sella turcica.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Due to the elevated prevalence of gingivitis, caries, and malocclusion, a multidisciplinary approach including dental follow\u2010ups should be the standard care in NS patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/scd.12780","type":"journal-article","created":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T04:29:11Z","timestamp":1663561751000},"page":"492-500","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Oral manifestations of eleven individuals with Noonan syndrome. A case series"],"prefix":"10.1111","volume":"43","author":[{"given":"Konstantina","family":"Vavetsi","sequence":"first","affiliation":[{"name":"Department of Periodontology National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga","family":"Panagopoulou","sequence":"additional","affiliation":[{"name":"Paediatric Dentist Private Practice  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0397elen","family":"Fryssira","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Spyridon A.","family":"Bobetsis","sequence":"additional","affiliation":[{"name":"Orthodontist Private Practice  Athens 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