{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:01:11Z","timestamp":1747188071725,"version":"3.40.5"},"reference-count":71,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T00:00:00Z","timestamp":1675123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Special Care in Dentistry"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To review the existing evidence on the adjuvant use of autologous platelet concentrates (APCs) with iliac crest bone graft (ICBG) in the reconstruction of the secondary alveolar cleft.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Electronic databases were searched systematically until November 2022. Clinical trials comparing the three\u2010dimensional radiological outcomes of patients who underwent secondary alveolar bone grafting (SABG) with ICBG and APCs to those with ICBG alone and the radiological outcomes assessed 6\u00a0months after surgery were included. Two authors performed the study selection and the assessment of the risk of bias. Meta\u2010analysis was performed using the random\u2010effects model to determine the risk ratio (RR) for developing wound dehiscence and the mean difference (MD) with a 95% confidence interval (CI) for the percentage of newly formed bone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine studies (seven RCT and two CCT) were included with a low to high risk of bias. At the 6\u2010month follow\u2010up, the study group revealed insignificant results regarding the percentage of newly formed bone (MD\u00a0=\u00a06.49; 95% CI: \u22120.97, 13.94; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.09; \u03c7<jats:sup>2<\/jats:sup>\u00a0=\u00a00.01; I<jats:sup>2<\/jats:sup>\u00a0=\u00a071%). In addition, the overall risk of developing wound dehiscence was lower in the study group (RR\u00a0=\u00a00.34; 95% CI: 0.15, 0.78; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.01; \u03c7<jats:sup>2<\/jats:sup>\u00a0=\u00a00.67; I<jats:sup>2<\/jats:sup>\u00a0=\u00a00%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Currently, there is insufficient evidence to support the adjuvant use of APCs with ICBG on enhanced bone regeneration following secondary alveolar bone grafting. However, combining ICBG and APCs might be beneficial in reducing the risk of developing wound dehiscence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/scd.12830","type":"journal-article","created":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T06:00:21Z","timestamp":1675231221000},"page":"12-27","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of adjuvant autologous platelet concentrates on secondary repair of alveolar clefts: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4950-4993","authenticated-orcid":false,"given":"Hamza Parvez","family":"Siddiqui","sequence":"first","affiliation":[{"name":"Division of Orthodontics and Dentofacial Deformities Centre for Dental Education and Research All India Institute of Medical Sciences  New Delhi India"},{"name":"College of Medical, Veterinary &amp; Life Sciences University of Glasgow  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