{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:41:15Z","timestamp":1789170075240,"version":"build-2803163510"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T00:00:00Z","timestamp":1684800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Special Care in Dentistry"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aimed to assess the overall incidence of osteonecrosis of the jaw (ONJ) caused by bisphosphonates and denosumab when used for controlling bone cancer metastasis or as adjuvant therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>A systematic search of the PubMed, Embase, and Cochrane Library databases and major meetings\u2019 proceedings as of July 30, 2022, identified randomized controlled trials (RCTs) and observational trials that evaluated ONJ caused by denosumab or bisphosphonates. The total incidence and risk ratio (RR) for ONJ were calculated using a random\u2010effects model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 42\u00a0003 patients with various solid tumors reported in 23 RCTs were included. The overall ONJ incidence in cancer patients receiving denosumab or bisphosphonates was 2.08% (95% CI 1.37\u20132.91; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a094.99%). Patients receiving denosumab had a higher ONJ incidence than those receiving bisphosphonates (RR 1.64, 95% CI 1.10\u20132.44; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a065.4%). Subgroup analyses showed that prostate cancer patients receiving denosumab and receiving zoledronic acid had the highest ONJ incidences, 5.0% and 3.0%, respectively. The incidence of ONJ induced by different doses was also different.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The incidence of ONJ caused by denosumab and bisphosphonates is low, the dose of the drug and the type of cancer have certain influence on ONJ. Therefore, clinicians should use the drug reasonably to improve the quality of life of patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/scd.12877","type":"journal-article","created":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T12:48:59Z","timestamp":1684846139000},"page":"530-541","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Incidence rate of osteonecrosis of jaw after cancer treated with bisphosphonates and denosumab: A systematic review and meta\u2011analysis"],"prefix":"10.1111","volume":"44","author":[{"given":"Chengrong","family":"Zhang","sequence":"first","affiliation":[{"name":"Breast Disease Diagnosis and Treatment Center of Affiliated Hospital of Qinghai University &amp; Affiliated Cancer Hospital of Qinghai University  Xining China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoshuang","family":"Shen","sequence":"additional","affiliation":[{"name":"Breast Disease Diagnosis and Treatment Center of Affiliated Hospital of Qinghai University &amp; Affiliated Cancer Hospital of Qinghai University  Xining China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Breast Medical Oncology Shandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Sciences  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanfang","family":"Xin","sequence":"additional","affiliation":[{"name":"Breast Disease Diagnosis and Treatment Center of Affiliated Hospital of Qinghai University &amp; Affiliated Cancer Hospital of Qinghai University  Xining China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingqiang","family":"Shi","sequence":"additional","affiliation":[{"name":"Breast Disease Diagnosis and Treatment Center of Affiliated Hospital of Qinghai University &amp; Affiliated Cancer Hospital of Qinghai University  Xining China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghui","family":"Zheng","sequence":"additional","affiliation":[{"name":"Breast Disease Diagnosis and Treatment Center of Affiliated Hospital of Qinghai University &amp; Affiliated Cancer Hospital of Qinghai University  Xining China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaozhou","family":"Wang","sequence":"additional","affiliation":[{"name":"Breast Disease Diagnosis and Treatment Center of Affiliated Hospital of Qinghai University &amp; Affiliated Cancer Hospital of Qinghai University  Xining China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Liu","sequence":"additional","affiliation":[{"name":"Breast Disease Diagnosis and Treatment Center of Affiliated Hospital of Qinghai University &amp; Affiliated Cancer Hospital of Qinghai University  Xining China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Breast Disease Diagnosis and Treatment Center of Affiliated Hospital of Qinghai University &amp; Affiliated Cancer Hospital of Qinghai University  Xining China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuxing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Breast Disease Diagnosis and Treatment Center of Affiliated Hospital of Qinghai University &amp; Affiliated Cancer Hospital of Qinghai University  Xining China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dengfeng","family":"Ren","sequence":"additional","affiliation":[{"name":"Breast Disease Diagnosis and Treatment Center of Affiliated Hospital of Qinghai University &amp; Affiliated Cancer Hospital of Qinghai University  Xining China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1266-8943","authenticated-orcid":false,"given":"Jiuda","family":"Zhao","sequence":"additional","affiliation":[{"name":"Breast Disease Diagnosis and Treatment Center of Affiliated Hospital of Qinghai University &amp; Affiliated Cancer Hospital of Qinghai University  Xining China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2013.08.013"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.5489\/cuaj.12149"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010020\u201000216\u20103"},{"key":"e_1_2_9_5_1","unstructured":"Mechanism of action pharmacokinetic and pharmacodynamic profile and clinical applications of nitrogen\u2010containing bisphosphonates \u2010 PubMed. 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