{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T23:51:24Z","timestamp":1789775484390,"version":"4.0.1"},"reference-count":51,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,5,27]],"date-time":"2023-05-27T00:00:00Z","timestamp":1685145600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Special Care in Dentistry"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Williams syndrome (WS) is a congenital developmental disorder characterized, mainly, by distinctive facial features, cardiovascular anomalies, growth delay and a typical neurobehavioral profile. The oral manifestations have not been sufficiently described and, therefore, the aim of the current study was to present the clinical, radiographic and microbiological findings of individuals with WS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>A series of nine WS individuals (seven females) with mean age 21 years\u2010old were evaluated. A complete intraoral clinical examination, a radiographic analysis using panoramic and cephalometric x\u2010ray and a supra\u2010 and sub\u2010gingival microbiological profiling were performed. We observed abnormal tooth morphology, excessive interdental spacing, congenitally missing permanent teeth and malocclusion. High levels of DMFT were observed and gingivitis was present in all subjects. Bacteria related to periodontal disease were detected in dental plaque. Three patients were classified with a gingival phenotype type I according to the Maynard and Wilson classification. The sella turcica bridging was a novel finding for this group of patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Due to the elevated prevalence of gingivitis, caries and malocclusion, a multidisciplinary approach including dental follow\u2010ups should be the standard of care in WS patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/scd.12881","type":"journal-article","created":{"date-parts":[[2023,5,27]],"date-time":"2023-05-27T14:05:18Z","timestamp":1685196318000},"page":"438-449","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Oral manifestations of nine individuals with Williams syndrome. A case series"],"prefix":"10.1111","volume":"44","author":[{"given":"Konstantina","family":"Vavetsi","sequence":"first","affiliation":[{"name":"Dental Sciences, School of Dentistry National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Panagopoulou","sequence":"additional","affiliation":[{"name":"Paediatric Dentist Private Practice  Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Koromantzos","sequence":"additional","affiliation":[{"name":"Department of Periodontology National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0397elen","family":"Fryssira","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spyridon A.","family":"Bobetsis","sequence":"additional","affiliation":[{"name":"Orthodontist Private Practice  Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitris","family":"Emmanouil","sequence":"additional","affiliation":[{"name":"National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiorgos A.","family":"Bobetsis","sequence":"additional","affiliation":[{"name":"Department of Periodontology National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/088307380201700406"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/6.3.465"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.24.6.1311"},{"issue":"5","key":"e_1_2_6_5_1","first-page":"1156","article-title":"Deletions of the elastin gene at 7q11.23 occur in approximately 90% of patients with Williams syndrome","volume":"56","author":"Nickerson E","year":"1995","journal-title":"Am J Hum Genet"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5200812"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1086\/498396"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119432692.ch63"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI35309"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.63.7.809"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320520309"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951100007356"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-010-0827-2"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.10.1947"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.30261"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(88)80272-5"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.30286"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.26.6.1235"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0993-11"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-008-8401-y"},{"issue":"4","key":"e_1_2_6_21_1","first-page":"262","article-title":"Williams syndrome\u2013oral presentation of 45 cases","volume":"16","author":"Hertzberg J","year":"1994","journal-title":"Pediatr Dent"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/scd.12361"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03262626"},{"issue":"11","key":"e_1_2_6_24_1","first-page":"447","article-title":"Odontostomatological aspects in patients with Williams syndrome: a series of 4 cases","volume":"62","author":"Cingano L","year":"2013","journal-title":"Minerva Stomatol"},{"issue":"2","key":"e_1_2_6_25_1","first-page":"105","article-title":"The elfin face: craniofacial and dental aspects of the Williams\u2010Beuren syndrome","volume":"31","author":"Maurino V","year":"2017","journal-title":"J Biol Regul Homeost Agents"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/cga.12316"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/ocr.12541"},{"issue":"4","key":"e_1_2_6_28_1","first-page":"301","article-title":"Williams syndrome","volume":"19","author":"Oncag A","year":"1995","journal-title":"J Clin Pediatr Dent"},{"issue":"7","key":"e_1_2_6_29_1","first-page":"375","article-title":"Modifications of periodontal tissues associated with Williams syndrome. A case report","volume":"58","author":"Canargiu F","year":"2009","journal-title":"Minerva Stomatol"},{"issue":"1","key":"e_1_2_6_30_1","first-page":"e1","article-title":"Martelli\u2010J\u00fanior H. Oral findings in Williams\u2010Beuren syndrome","volume":"23","author":"Ferreira SB","year":"2018","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1979.50.4.170"},{"issue":"1","key":"e_1_2_6_32_1","first-page":"55","article-title":"Guidelines for prevalence studies of dental caries","volume":"1","author":"Palmer JD","year":"1984","journal-title":"Community Dent Health"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1972.43.1.38"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.090590"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00822.x"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9416(81)90099-3"},{"issue":"4","key":"e_1_2_6_37_1","first-page":"788","article-title":"\u201cCheckerboard\u201d DNA\u2010DNA hybridization","volume":"17","author":"Socransky SS","year":"1994","journal-title":"Biotechniques"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.070350"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1998.tb02419.x"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/6.7.1029"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.21311"},{"issue":"1","key":"e_1_2_6_42_1","first-page":"29","article-title":"Caries prevalence of 5, 12 and 15\u2010year\u2010old Greek children: a national pathfinder survey","volume":"29","author":"Oulis CJ","year":"2012","journal-title":"Community Dent Health"},{"key":"e_1_2_6_43_1","volume-title":"Dental Caries (Tooth Decay) in Adolescents (Age 12 to 19)","author":"National Institute of Dental and Craniofacial Research"},{"key":"e_1_2_6_44_1","volume-title":"Dental Caries (Tooth Decay) in Children Age 2 to 11","author":"National Institute of Dental and Craniofacial Research"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.4103\/JISPPD.JISPPD_204_18"},{"issue":"2","key":"e_1_2_6_46_1","first-page":"179","article-title":"Supravalvular aortic stenosis. Clinical and pathologic observations in six patients","volume":"109","author":"O'Connor WN","year":"1985","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1086\/341035"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302x.2004.00168.x"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.6.885"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.5114\/pjr.2018.76153"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/cjl032"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/cjp081"}],"container-title":["Special Care in Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/scd.12881","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T13:57:11Z","timestamp":1710424631000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/scd.12881"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,27]]},"references-count":51,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1111\/scd.12881"],"URL":"https:\/\/doi.org\/10.1111\/scd.12881","archive":["Portico"],"relation":{},"ISSN":["0275-1879","1754-4505"],"issn-type":[{"value":"0275-1879","type":"print"},{"value":"1754-4505","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,27]]},"assertion":[{"value":"2023-02-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}