{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T08:10:00Z","timestamp":1779264600604,"version":"3.51.4"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T00:00:00Z","timestamp":1696809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T00:00:00Z","timestamp":1696809600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Special Care in Dentistry"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare the expression of IL\u201017 in periapical lesions (cysts and granulomas) among elderly individuals and adults. We selected 20 periapical lesions of the elderly (12 granulomas and eight cysts) and 20 periapical lesions of adults (12 granulomas and eight cysts).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Immunohistochemistry was performed using a specific antibody for IL\u201017. The slides were subdivided into five high magnification fields and then the images were observed through an optical microscope. According to the number of positive markings for the antibody, grades were given, ranging from 0 to 2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The results demonstrate that there was no statistical difference when comparing the expression of IL\u201017 between cysts and granulomas of both groups (study group: cysts 0.7\u00a0\u00b1\u00a00.21 \u00d7 granulomas 0.96\u00a0\u00b1\u00a00.58,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.61; control group: cysts 0.37\u00a0\u00b1\u00a00.16 \u00d7 granulomas 0.31\u00a0\u00b1\u00a00.23,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.27). The comparison between adult (control group) and elderly patients (study group) showed a statistical difference both in cysts (study group: 0.7\u00a0\u00b1\u00a00.21 \u00d7 control group: 0.37\u00a0\u00b1\u00a00.16,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.007) and in granulomas (study group: 0.96\u00a0\u00b1\u00a00.58 \u00d7 control group: 0.31\u00a0\u00b1\u00a00.23,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.0009), in which elderly patients had a higher expression of interleukin 17, in relation to adult patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We concluded that elderly patients have a higher expression of IL\u201017 in both cysts and granulomas, when compared to adult patients.<\/jats:p>\n                  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Rocha","family":"Bastos","sequence":"additional","affiliation":[{"name":"Post\u2010graduate Program in Dentistry Est\u00e1cio de S\u00e1 University  Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7559-2555","authenticated-orcid":false,"given":"Alexandre Marques Paes da","family":"Silva","sequence":"additional","affiliation":[{"name":"Post\u2010graduate Program in Dentistry Est\u00e1cio de S\u00e1 University  Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e1bio Ram\u00f4a","family":"Pires","sequence":"additional","affiliation":[{"name":"Post\u2010graduate Program in Dentistry Est\u00e1cio de S\u00e1 University  Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4166-3284","authenticated-orcid":false,"given":"Dennis de 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