{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T16:01:54Z","timestamp":1776182514823,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T00:00:00Z","timestamp":1704153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Special Care in Dentistry"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Oral candidosis is common in patients with end\u2010of\u2010life cancer; however, its prognosis is unclear. We aimed to assess oral candidosis and Candida species as prognostic indicators in palliative care for these patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We consecutively included palliative care patients, assessed for candidosis via microbiological techniques, and classified into three groups by the extent of oral lesions. The association between oral candidosis and overall survival was assessed using a Cox proportional hazards model adjusted by performance status (PS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We studied 142 patients (median age 77; 52.8% women) with a 76.1% oral candidosis prevalence.\n                      <jats:italic>Candida albicans<\/jats:italic>\n                      (80.6%) was the most common species. Oral lesions were classified as none, grade 1 (28.7%), or \u2265 grade 2 (14.8%). During follow\u2010up, Cox models identified \u2265grade 2 lesions (aHR\u00a0=\u00a02.04; 95% CI: 1.18\u20133.54;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.011) and\n                      <jats:italic>Candida tropicalis<\/jats:italic>\n                      (aHR\u00a0=\u00a02.38; 95% CI: 1.03\u20135.55;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.044) as predictors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The extent of oral candidosis lesions or the presence of\n                      <jats:italic>C. tropicalis<\/jats:italic>\n                      may serve as prognostic indicator in patients with end\u2010of\u2010life cancer. Therefore, solely concentrating on the prevalence and frequency of fungal species may be insufficient for predicting life prognosis; it is advisable to assess these parameters through both visual examination and culture.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/scd.12955","type":"journal-article","created":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T00:13:25Z","timestamp":1704240805000},"page":"1097-1106","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Oral candida lesions and\n                    <i>Candida tropicalis<\/i>\n                    : Potential prognostic markers in end\u2010of\u2010life cancer patients"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1734-9447","authenticated-orcid":false,"given":"Maiko","family":"Shimosato","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery National Hospital Organization Kyoto Medical Center  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinpei","family":"Kada","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Otsu Red Cross Hospital  Otsu Shiga Japan"},{"name":"Division of Clinical Research Planning and Management, Clinical Research Institute National Hospital Organization Kyoto Medical Center  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eriko","family":"Yase","sequence":"additional","affiliation":[{"name":"Department of Pharmacy National Hospital Organization Kyoto Medical Center  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Sakane","sequence":"additional","affiliation":[{"name":"Division of Preventive Medicine Clinical Research Institute National Hospital Organization Kyoto Medical Center  Kyoto 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