{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T09:47:37Z","timestamp":1771667257744,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,1,7]],"date-time":"2024-01-07T00:00:00Z","timestamp":1704585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Special Care in Dentistry"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A hamartoma is a benign proliferation of typical mature cells specific to a particular anatomical site. In the oral cavity, they may occur as isolated cases or be associated with genetic syndromes. Oral\u2010facial\u2010digital syndrome type VI is a rare genetic disorder with an estimated incidence of one in 50,000\u2013250,000 newborns. Here, we report a case of a 2\u2010year\u2010old boy diagnosed with oral\u2010facial\u2010digital syndrome type VI who was referred for evaluation of a bilateral and normochromic to slightly pinkish nodule on the lateral surface of the tongue. Clinically, the child presented hypotonia, low visual acuity, absence of oculocephalic reflex, delay in neuropsychomotor development, and polydactyly in the feet. Excisional biopsies of both sides of the tongue were performed using a 1.5\u00a0W high\u2010power diode laser (wavelength of 980\u00a0nm), and histopathological analysis revealed abundant mature adipocytes predominantly arranged in lobules that mainly surrounded the minor salivary gland parenchyma. The surgical sites healed with no complications and the patient remains under follow\u2010up for 10 months. Due to the limited literature on this syndrome and the frequent presence of tongue hamartomas in children, dentists need to be familiar with them.<\/jats:p>","DOI":"10.1111\/scd.12958","type":"journal-article","created":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T03:59:41Z","timestamp":1704686381000},"page":"1036-1040","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Bilateral lipomatous hamartoma of the tongue: A case report in a child with oral\u2010facial\u2010digital syndrome type VI"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9564-2318","authenticated-orcid":false,"given":"Aline","family":"Queiroz","sequence":"first","affiliation":[{"name":"Department of Stomatology School of Dentistry University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8205-9935","authenticated-orcid":false,"given":"Paulo S\u00e9rgio Souza","family":"Pina","sequence":"additional","affiliation":[{"name":"Department of Stomatology School of Dentistry University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myrian Stella Paiva","family":"Novaes","sequence":"additional","affiliation":[{"name":"Clinician of Special Laboratory of Laser in Dentistry (LELO) University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz","family":"Dutra","sequence":"additional","affiliation":[{"name":"Department of Stomatology School of Dentistry University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9708-9608","authenticated-orcid":false,"given":"Suzana Cantanhede Orsini Machado","family":"de Sousa","sequence":"additional","affiliation":[{"name":"Clinician of Special Laboratory of Laser in Dentistry (LELO) University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciane Hiramatsu","family":"Azevedo","sequence":"additional","affiliation":[{"name":"Clinician of Special Laboratory of Laser in Dentistry (LELO) University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750\u20101172\u20107\u20104"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2013.03.004"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2018.03.012"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750\u20101172\u20105\u201020"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40368\u2010015\u20100193\u20109"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2022.06.009"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.29284"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3180674dd7"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13630\u2010016\u20100034\u20104"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1597\/08\u2010200_1"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973\u2010029X.164553"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399\u20100004.1971.tb00285.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/605892"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0b013e318275ee68"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399\u20100004.1975.tb01495.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedex.2008.09.005"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31976"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100560.1994.tb00254.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2007.09.170"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000006138"},{"issue":"39","key":"e_1_2_6_22_1","first-page":"2017","article-title":"A V\u00e1radi\u2010Papp\u2010szindr\u00f3ma (VI\u2010os t\u00edpus\u00fa orofaciodigitalis szindr\u00f3ma) 25 eves t\u00f6rt\u00e9nete [25 years' history of V\u00e1radi\u2010Papp syndrome (orofaciodigital syndrome VI)","volume":"146","author":"V\u00e1radi V","year":"2005","journal-title":"Orv Hetil"}],"container-title":["Special Care in 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