{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T01:27:38Z","timestamp":1789694858656,"version":"4.0.1"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T00:00:00Z","timestamp":1710374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Special Care in Dentistry"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To identify radiographic findings suggestive of drug\u2010induced osteonecrosis and evaluate radiomorphometric patterns indicative of changes in bone mineral density in individuals transplanted for liver disorders using bisphosphonates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>The study group included panoramic x\u2010rays of liver transplant patients who are being monitored and who present a clinical status of osteoporosis and use bisphosphonates. The control group was made up of liver transplant patients who did not have osteoporosis. On panoramic radiographs, mental index (MI) and mandibular cortical index (MCI) and the presence of radiographic anomalies suggestive of osteonecrosis were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were significant statistical results when comparing the groups in relation to the decrease in bone mineral density (BMD) with MCI\u2010C3 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.036), however, there were none in relation to MI (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.14). There were no valid statistical results when relating MCI (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.94) and MI (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.66) with reduced BMD and use of bisphosphonates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Liver transplant individuals using bisphosphonates present greater radiographic signs of bone sclerosis suggestive of a greater propensity to develop osteonecrosis of the jaw and an increased risk of presenting changes suggestive of reduced bone mineral density on panoramic radiographs when compared to liver transplant individuals not using bisphosphonates.<\/jats:p><\/jats:sec>","DOI":"10.1111\/scd.12992","type":"journal-article","created":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T07:25:40Z","timestamp":1710401140000},"page":"1273-1279","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Bone pattern changes in post liver transplant patients using bisphosphonates"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8886-7172","authenticated-orcid":false,"given":"Marcus Vin\u00edcius","family":"Bueno","sequence":"first","affiliation":[{"name":"Department of Dentistry, Central Institute Clinical Hospital of Medical School of the University of S\u00e3o Paulo  S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2375-5935","authenticated-orcid":false,"given":"Luciana","family":"Munhoz","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Public Health and Forense Dentistry School of Dentistry of University of S\u00e3o Paulo  Ribeir\u00e3o Preto SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9573-2858","authenticated-orcid":false,"given":"Karem L.","family":"Ortega","sequence":"additional","affiliation":[{"name":"Oral Medicine, Oral Surgery and Implantology, Unit (MedOralRes), Faculty of Medicine and Dentistry University of Santiago de Compostela  Santiago de Compostela Spain"},{"name":"Department of Stomatology, School of Dentistry, University of S\u00e3o Paulo S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4698-3976","authenticated-orcid":false,"given":"Maria Paula Siqueira de Melo","family":"Peres","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Central Institute Clinical Hospital of Medical School of the University of S\u00e3o Paulo  S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7787-4062","authenticated-orcid":false,"given":"Juliana Bertoldi","family":"Franco","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Central Institute Clinical Hospital of Medical School of the University of S\u00e3o Paulo  S\u00e3o Paulo SP Brazil"},{"name":"Department of Dentistry, Children and Adolescents Institute Clinical Hospital of Medical School of the University of S\u00e3o Paulo  S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.12968\/denu.2013.40.10.805"},{"key":"e_1_2_8_3_1","article-title":"Assessment of laboratory tests and intraoperative bleeding in patients with liver cirrhosis undergoing tooth extractions","volume":"00","author":"Franco JB","year":"2021","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1678-77572012000200020"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.disamonth.2008.03.006"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2018.04.007"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.13887"},{"issue":"3","key":"e_1_2_8_8_1","first-page":"185","article-title":"Hepatic osteodystrophy","volume":"11","author":"Gatta A","year":"2014","journal-title":"Clin Cases Miner Bone Metab"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-010-0166-4"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13730"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/scd.12747"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1592367"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2011.03.007"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20174270"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2010.05.030"},{"key":"e_1_2_8_16_1","unstructured":"PJ G S C.Liver transplantation in adults: Long\u2010term management of transplant recipients. . 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