{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T19:48:31Z","timestamp":1761767311033,"version":"3.40.5"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,3,31]],"date-time":"2024-03-31T00:00:00Z","timestamp":1711843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Special Care in Dentistry"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia (CREST) syndrome is an acronym for the clinical features that are seen. Its etiology is unknown, affecting women three times more than men. CREST syndrome is often diagnosed by systemic symptoms. However, oral manifestations could be helpful in the early diagnosis of the disease. Less than 20 cases of CREST syndrome with oral symptoms were described.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To report a case of a 26\u2010year\u2010old female, who was diagnosed with CREST syndrome based on findings of the oral mucosa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case report<\/jats:title><jats:p>Clinical examination revealed sclerodactyly and nail alterations. Oral findings were associated with hypochromic and paleness mucosa. The tongue was strongly rigid and reddish areas compatible with telangiectasias were found. The mouth opening was particularly compromised. Histological findings were suggestive of systemic sclerosis in the context of CREST syndrome. Considering the available diagnosis criteria, this case was diagnosed as CREST syndrome based on oral manifestations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Oral manifestations of CREST syndrome could help in early clinical diagnosis, preventing a delay in the onset of an aggressive form of the disease. Accurate referrals of patients to specialists are needed for a multidisciplinary approach.<\/jats:p><\/jats:sec>","DOI":"10.1111\/scd.12998","type":"journal-article","created":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T04:29:37Z","timestamp":1711945777000},"page":"1368-1376","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["CREST syndrome diagnosed by oral lesions: A case report and review of the literature"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5201-1444","authenticated-orcid":false,"given":"Gerardo","family":"Gilligan","sequence":"first","affiliation":[{"name":"Oral Medicine Department Facultad de Odontolog\u00eda Universidad Nacional de C\u00f3rdoba  Cordoba Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicol\u00e1s","family":"Leonardi","sequence":"additional","affiliation":[{"name":"Oral Medicine Department School of Dentistry Health Sciences Faculty Universidad Cat\u00f3lica de C\u00f3rdoba  C\u00f3rdoba Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Sambuelli","sequence":"additional","affiliation":[{"name":"General Pathology Department Cl\u00ednica Universitaria Reyna Fabiola  C\u00f3rdoba Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e9","family":"Panico","sequence":"additional","affiliation":[{"name":"Oral Medicine Department Facultad de Odontolog\u00eda Universidad Nacional de C\u00f3rdoba  Cordoba Argentina"},{"name":"Oral Medicine Department School of Dentistry Health Sciences Faculty Universidad Cat\u00f3lica de C\u00f3rdoba  C\u00f3rdoba Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3,31]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"Beltr\u00e1n\u2010VeraAD Cuzco\u2010Mac\u00edasAC Cuzco\u2010Mac\u00edasLG Obreg\u00f3n\u2010OrtegaLG Coloma\u2010Gaibor ML.Esclerosis Sist\u00e9mica Progresiva con S\u00edndrome de CREST. Reporte de Caso. Published online.2023. doi:10.5281\/ZENODO.7605530"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14458"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0000000000000491"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S361667"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440\u20100960.2003.06301.x"},{"key":"e_1_2_7_7_1","unstructured":"Silvari\u00f1oR RebellaM AlonsoJ CairoliE Manifestaciones cl\u00ednicas en pacientes con esclerosis sist\u00e9mica.2009;25."},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0755\u20104982(06)74930\u20102"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2019.01.008"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20102600(19)30480\u20101"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016\u2010022\u201008945\u2010x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2018.07.008"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000963"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.141020"},{"issue":"7","key":"e_1_2_7_15_1","first-page":"324","article-title":"Oral medicine case book 62: CREST syndrome","volume":"69","author":"Bunn BK","year":"2014","journal-title":"SADJ"},{"issue":"9","key":"e_1_2_7_16_1","first-page":"443","article-title":"Scleroderma and CREST syndrome: a case report in dentistry","volume":"60","author":"Lauritano D","year":"2011","journal-title":"Minerva Stomatol"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1999.70.5.536"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18105238"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000539"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.4103\/0972\u2010124X.99275"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1984.55.3.175"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102013\u2010204424"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.12285"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13256\u2010016\u20101086\u20101"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.23736\/S0392\u20100488.18.05922\u20109"},{"issue":"3","key":"e_1_2_7_26_1","first-page":"183","article-title":"[CREST syndrome]","volume":"153","author":"Meyer O","year":"2002","journal-title":"Ann Med Interne"}],"container-title":["Special Care in Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/scd.12998","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T12:02:43Z","timestamp":1732017763000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/scd.12998"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,31]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1111\/scd.12998"],"URL":"https:\/\/doi.org\/10.1111\/scd.12998","archive":["Portico"],"relation":{},"ISSN":["0275-1879","1754-4505"],"issn-type":[{"type":"print","value":"0275-1879"},{"type":"electronic","value":"1754-4505"}],"subject":[],"published":{"date-parts":[[2024,3,31]]},"assertion":[{"value":"2024-01-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}