{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:30:32Z","timestamp":1792672232470,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T00:00:00Z","timestamp":1727395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T00:00:00Z","timestamp":1727395200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Special Care in Dentistry"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This systematic review evaluated the main clinical, radiographic, histopathological and treatment\u2010related characteristics of ligneous gingivitis (LG) and periodontitis (LP) in individuals with plasminogen deficiency (PD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>Studies in humans diagnosed with PD, focusing on the evaluation of oral characteristics and treatment of the LG\/LP were considered for inclusion criteria. Electronic searches were performed up to April 2024 in five databases and in the grey literature. Risk of bias was assessed according to the Joanna Briggs Institute Critical Appraisal Checklists for case reports. It was provided a narrative synthesis of the results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 17 studies were included. All were case reports that analyzed 17 individuals with PD who presented with LG\/LP. The relative frequency of PD type I was 56%, while type II constitutes the remaining 44%. In most studies, patients exhibited ulceration clinically, bone loss radiographically, and subepithelial eosinophilic material accumulation on histopathological evaluation. Conventional periodontal scaling was the most used management. All included studies provided well\u2010described clinical characteristics and confirmed plasminogen deficiency through laboratory testing. Only three studies had a risk of bias values lower than 15%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Current evidence is limited and varied, complicating the diagnosis and treatment of GL\/PL. Future studies should provide a more detailed account of treatments and include extended clinical and radiographic follow\u2010up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/scd.13068","type":"journal-article","created":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T00:14:04Z","timestamp":1727482444000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Main oral characteristics and treatment of ligneous gingivitis and periodontitis in individuals with plasminogen deficiency: A systematic review"],"prefix":"10.1111","volume":"45","author":[{"given":"Diego Belmiro do Nascimento","family":"Santos","sequence":"first","affiliation":[{"name":"Department of Pathology and Oral Diagnosis School of Dentistry, Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9454-8402","authenticated-orcid":false,"given":"Larissa Conrado","family":"da Silva","sequence":"additional","affiliation":[{"name":"Department of Pathology and Oral Diagnosis School of Dentistry, Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle do Vale Dantas","family":"da Silva","sequence":"additional","affiliation":[{"name":"Department of Pathology and Oral Diagnosis School of Dentistry, Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3259-606X","authenticated-orcid":false,"given":"Bruno Augusto Benevenuto","family":"de Andrade","sequence":"additional","affiliation":[{"name":"Department of Pathology and Oral Diagnosis School of Dentistry, Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1026-9401","authenticated-orcid":false,"given":"Lucianne Cople","family":"Maia","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Pediatric Dentistry School of Dentistry, Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6986-9148","authenticated-orcid":false,"given":"Jefferson R.","family":"Ten\u00f3rio","sequence":"additional","affiliation":[{"name":"Department of Pathology and Oral Diagnosis School of Dentistry, Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020008951"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtha.2023.07.013"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20191865"},{"issue":"2","key":"e_1_2_7_5_1","first-page":"213","article-title":"Ligneous periodontal lesions in a young child with severe plasminogen deficiency: a case report","volume":"15","author":"Galeotti A","year":"2014","journal-title":"Eur J Paediatr Dent"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060422"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2016.07.013"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11239\u2010016\u20101416\u20106"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/1119\u20103077.224133"},{"key":"e_1_2_7_10_1","unstructured":"AromatarisE LockwoodC PorrittK PillaB JordanZ editors.JBI Manual for Evidence Synthesis.2024. 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