{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T09:24:09Z","timestamp":1773048249093,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T00:00:00Z","timestamp":1729641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T00:00:00Z","timestamp":1729641600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Special Care in Dentistry"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Two biomarkers that are gaining attention for their roles in the progression of both periodontal and cardiovascular diseases are vitronectin and fetuin\u2010A. This study evaluated vitronectin and fetuin\u2010A expression in saliva samples of periodontitis (P) patients with and without coronary artery disease (CAD) after scaling and root planing (SRP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sixty patients were divided into three groups: PH\u00a0+\u00a0SH (periodontally and systemically healthy), P (stage II\/III grade B periodontitis), and P\u00a0+\u00a0CAD (periodontitis with CAD). Demographic, periodontal, and cardiac parameters were recorded. Unstimulated saliva samples were collected at baseline (day 0) and after SRP. On day 90, periodontal parameters and vitronectin\/fetuin\u2010A expression were reassessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      P\u00a0+\u00a0CAD patients had higher age, weight, BMI, and lower income (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.001,\u00a0.025,\u00a0.002,\u00a0&lt;\u00a0.001, respectively), along with elevated plaque index, bleeding on probing, probing pocket depth, and reduced clinical attachment levels (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.001). Vitronectin was elevated, while fetuin\u2010A was lower in P\u00a0+\u00a0CAD, but both improved post\u2010SRP (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Enhanced vitronectin and fetuin\u2010A levels post\u2010SRP indicate their potential as biomarkers and therapeutic targets for both periodontal and CAD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/scd.13073","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T09:33:57Z","timestamp":1729676037000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Improvement of salivary biomarkers vitronectin and fetuin\u2010A levels in periodontitis patients with coronary artery disease post scaling and root planing"],"prefix":"10.1111","volume":"45","author":[{"given":"Jaideep","family":"Mahendra","sequence":"first","affiliation":[{"name":"Department of Periodontics Meenakshi Ammal Dental College and Hospital Chennai Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavithra","family":"Dave","sequence":"additional","affiliation":[{"name":"Department of Periodontics Meenakshi Ammal Dental College and Hospital Chennai Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lakshmi","family":"Priya","sequence":"additional","affiliation":[{"name":"Department of Periodontics Meenakshi Ammal Dental College and Hospital Chennai Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moongilpatti","family":"Arumugam","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kilpauk Medical College and Hospital Chennai Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pradeep Kumar","family":"Yadalam","sequence":"additional","affiliation":[{"name":"Department of Periodontics Saveetha Dental College, SIMATS, Saveetha University Chennai Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3663-1416","authenticated-orcid":false,"given":"Carlos M.","family":"Ardila","sequence":"additional","affiliation":[{"name":"Basic Sciences Department, Faculty of Dentistry Biomedical Stomatology Research Group, Universidad de Antioquia Medell\u00edn Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8081135"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma11101802"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2020.625579"},{"issue":"2","key":"e_1_2_10_5_1","first-page":"72","article-title":"Prevalence of periodontal disease, its association with systemic diseases and prevention","volume":"11","author":"Nazir MA","year":"2017","journal-title":"Int J Health 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