{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T09:18:45Z","timestamp":1773047925504,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:00:00Z","timestamp":1737936000000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Special Care in Dentistry"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Aplastic anemia (AA) is a rare condition that frequently manifests with pancytopenia. Management of severe disease is through either allogenic stem cell transplantation or immunosuppressive therapy with supportive care. Drug\u2010induced gingival overgrowth (DIGO) is a potential complication of a number of medications, including cyclosporine and amlodipine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Report<\/jats:title>\n                    <jats:p>The following report presents the case of a male child who was diagnosed with severe AA at 7 years of age. He was managed with immunosuppressive therapy and developed DIGO as a side effect of treatment, exacerbated by poor oral hygiene. Nonsurgical and surgical management strategies were utilized. Gingival debulking surgery was completed at 9 years of age, once the patient's condition had stabilized. Postoperative care included regular dental prophylaxis and oral hygiene instruction. The patient's medical condition remained stable, and his oral health was maintained without relapse of DIGO.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case emphasizes the importance of coordinated care for managing DIGO in immunocompromised pediatric patients and describes the successful management of DIGO using both nonsurgical and surgical methods.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/scd.13106","type":"journal-article","created":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T00:14:26Z","timestamp":1738023266000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gingival Debulking Surgery for a Child With Severe Aplastic Anemia: A Case Report"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7540-1041","authenticated-orcid":false,"given":"Caitlin R.","family":"Hurley","sequence":"first","affiliation":[{"name":"Paediatric Dentistry The University of Western Australia Dental School  Perth Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9329-5241","authenticated-orcid":false,"given":"John","family":"Winters","sequence":"additional","affiliation":[{"name":"Department of Paediatric Dentistry Perth Children's Hospital  Nedlands Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4666-4691","authenticated-orcid":false,"given":"Melanie","family":"McAlpine","sequence":"additional","affiliation":[{"name":"Department of Paediatric Dentistry Perth Children's Hospital  Nedlands Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9173-5629","authenticated-orcid":false,"given":"Michelle","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Paediatric and Adolescent Oncology and Haematology Perth Children's Hospital  Nedlands Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6278-9762","authenticated-orcid":false,"given":"Robert P.","family":"Anthonappa","sequence":"additional","affiliation":[{"name":"Paediatric Dentistry The University of Western Australia Dental School  Perth Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.14996"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCP50AEEYGREWUZ"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12264"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24065448"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/oral1030023"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2000.027004217.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.1.3"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1993.tb01757.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.4322\/acr.2016.041"},{"issue":"7","key":"e_1_2_8_11_1","first-page":"467","article-title":"New Clinical Index for Drug\u2010Induced Gingival Overgrowth","volume":"30","author":"Ingles E.","year":"1999","journal-title":"Quintessence International"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2006.0219"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(91)90521-D"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24054544"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2020.10.020"},{"issue":"5","key":"e_1_2_8_16_1","first-page":"366","article-title":"Chlorhexidine as an Oral Hygiene Adjunct for Cyclosporine\u2010Induced Gingival Hyperplasia","volume":"57","author":"Saravia M.","year":"1990","journal-title":"ASDC Journal of Dentistry for Children"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(89)90270-3"},{"issue":"6","key":"e_1_2_8_18_1","first-page":"408","article-title":"Phenobarbital\u2010Induced Gingival Overgrowth? Report of Two Cases and Complications in Management","volume":"63","author":"Gregoriou A.","year":"1996","journal-title":"ASDC Journal of Dentistry for Children"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.17796\/jcpd.27.2.v70187716x08286q"},{"key":"e_1_2_8_20_1","article-title":"Phenytoin\u2010Induced Severe Gingival Overgrowth in a Child","volume":"2014","author":"Kumar R.","year":"2014","journal-title":"Case Reports"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764172.2017.1400165"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.33448\/rsd-v10i16.22597"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.4103\/0972-124X.113066"},{"issue":"1","key":"e_1_2_8_24_1","first-page":"77","article-title":"Bleeding Disorders of Importance in Dental Care and Related Patient Management","volume":"73","author":"Gupta A.","year":"2007","journal-title":"Journal of the Canadian Dental Association"}],"container-title":["Special Care in Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/scd.13106","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/scd.13106","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/scd.13106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T08:23:15Z","timestamp":1773044595000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/scd.13106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/scd.13106"],"URL":"https:\/\/doi.org\/10.1111\/scd.13106","archive":["Portico"],"relation":{},"ISSN":["0275-1879","1754-4505"],"issn-type":[{"value":"0275-1879","type":"print"},{"value":"1754-4505","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-06-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13106"}}