{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:20:13Z","timestamp":1787016013725,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T00:00:00Z","timestamp":1744070400000},"content-version":"vor","delay-in-days":38,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Special Care in Dentistry"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This case report describes the prosthetic rehabilitation of a 15\u2010year\u2010old female patient with a rare IFIH1\u2010related interferonopathy, presenting features from both Aicardi\u2010Gouti\u00e8res Syndrome (AGS) and Singleton\u2010Merten Syndrome (SMS). The report highlights the unique dental and maxillofacial challenges, and the multidisciplinary treatment approach required in such patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The patient underwent a comprehensive prosthetic rehabilitation, which included two stages of extractions, followed by the fabrication of a complete upper denture and a two\u2010implant\u2010retained mandibular overdenture. Pre\u2010 and post\u2010treatment assessments, including panoramic radiographs and cone beam computed tomography (CBCT), were utilized to guide treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Initial assessments revealed root formation anomalies, multiple impacted teeth, internal resorption, and associated dental anomalies. Following extractions and ridge augmentation, two freestanding implants were successfully placed in the anterior mandible, with no complications during osseointegration. The patient reported satisfaction with the function, esthetics, and stability of her dental prostheses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This case underscores the importance of a multidisciplinary approach for managing dental anomalies and bone fragility in patients with IFIH1\u2010related disorders. Early genetic diagnosis and thorough treatment planning are critical for successful prosthetic rehabilitation and optimal patient outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/scd.70026","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T06:44:48Z","timestamp":1744094688000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Diagnostic Odyssey and Full Mouth Rehabilitation of a Juvenile Patient With IFIH1\u2010Related Disorder: A Case of Aicardi\u2010Gouti\u00e8res and Singleton Merten Syndromes Overlap"],"prefix":"10.1111","volume":"45","author":[{"given":"Clive","family":"Friedman","sequence":"first","affiliation":[{"name":"Department of Paediatric Dentistry Schulich School of Medicine &amp; Dentistry Western University  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timucin","family":"Ari","sequence":"additional","affiliation":[{"name":"Department of Paediatric Dentistry Schulich School of Medicine &amp; Dentistry Western University  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcrkan","family":"\u00dcnsal","sequence":"additional","affiliation":[{"name":"Division of Oral and Maxillofacial Radiology Schulich School of Medicine &amp; Dentistry Western University  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5409-8387","authenticated-orcid":false,"given":"Tugce","family":"Balci","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Schulich School of Medicine &amp; Dentistry Western\u00a0University  London Ontario Canada"},{"name":"Medical Genetics Program of Southwestern Ontario London Health Sciences Centre  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Morrison","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery Schulich School of Medicine &amp; Dentistry Western\u00a0University  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6632-4698","authenticated-orcid":false,"given":"Nilgun","family":"Ari","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics Schulich Medicine and Dentistry Western University  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.5409\/wjcp.v12.i3.107"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v11.i11.2452"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2200367"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes12091403"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annder.2015.06.018"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.38214"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14073"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2017.0004"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.23975"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2016.03.005"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.62478"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2014.12.014"},{"issue":"3","key":"e_1_2_8_14_1","first-page":"93","article-title":"Management of Multiple Impacted Teeth: A Case Report and Review","volume":"6","author":"Ajith S. 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