{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T22:04:13Z","timestamp":1773612253374,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Special Care in Dentistry"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study aimed to compare periodontal health between thalassemia patients and healthy individuals by assessing the Simplified Oral Hygiene Index (OHI\u2010S) and the Community Periodontal Index (CPI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      This analytic case\u2013control study was conducted at two centers in Tehran, Iran, involving 80 thalassemia patients (case group) and 80 healthy individuals (control group), matched by sex and age (15\u201325 years). Demographic data, OHI\u2010S, and CPI were collected from all participants. For group comparisons, the Mann\u2013Whitney\n                      <jats:italic>U<\/jats:italic>\n                      test was used for non\u2010normally distributed data, while the Kruskal\u2013Wallis test was employed for multiple comparisons. Multiple logistic regression and ANOVA were also applied. All statistical analyses were conducted using SPSS version 20, with a significance level set at 0.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The two groups showed statistically significant differences in the CPI and OHI\u2010S indexes (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). The multiple logistic regression model revealed that thalassemia affects the OHI\u2010S index but not the CPI index.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients with thalassemia major experience more severe periodontal disease than healthy individuals. Given the study's limitations, further research is recommended to investigate the risk factors for periodontal problems in thalassemia patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/scd.70056","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:35:03Z","timestamp":1748306103000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of the Simplified Oral Hygiene Index and Community Periodontal Index in Patients With Major \u03b2\u2010Thalassemia: A Case\u2013Control Study"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2185-2400","authenticated-orcid":false,"given":"Foad","family":"Yahyapour","sequence":"first","affiliation":[{"name":"Faculty of Dentistry Shahed University  Tehran Iran"},{"name":"Pediatric Neurorehabilitation Research Center University of Social Welfare and Rehabilitation Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9036-5668","authenticated-orcid":false,"given":"Mozhgan","family":"Faezi","sequence":"additional","affiliation":[{"name":"Department of Community Oral Health Faculty of Dentistry Shahed University  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hassan","family":"Semyari","sequence":"additional","affiliation":[{"name":"Dental Faculty Shahed University  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6916-6514","authenticated-orcid":false,"given":"Nahid","family":"Rejeh","sequence":"additional","affiliation":[{"name":"Faculty of Nursing &amp; Midwifery Shahed University  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed Mohamad Kazem","family":"Nourbakhsh","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Imam Khomeini Hospital Complex Tehran University of Medical Sciences  Tehran Iran"},{"name":"Imam Khomeini Hospital Complex Tohid Square  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2039-1451","authenticated-orcid":false,"given":"Sara Monem","family":"Moharrer","sequence":"additional","affiliation":[{"name":"Pediatric Neurorehabilitation Research Center University of Social Welfare and Rehabilitation Sciences  Tehran Iran"},{"name":"Faculty of Dentistry Tehran Medical Sciences Islamic Azad University  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,26]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"149","volume-title":"The \u03b2Thalassaemia Syndromes","author":"Weatherall D.","year":"1981"},{"issue":"4","key":"e_1_2_8_3_1","first-page":"394","article-title":"The Impact of Thalassemia Major on Dental Integrity and Development","volume":"6","author":"Al\u2010Rubayee M. 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Patients With Major Beta\u2010Thalassemia","volume":"5","author":"Mehdizadeh M.","year":"2009","journal-title":"Dental Research Journal"},{"issue":"1","key":"e_1_2_8_11_1","first-page":"41","article-title":"Prevalence of Dental Caries, Oral Hygiene Status, Malocclusion Status and Dental Treatment Needs in Thalassemic Children\u2013A Cross Sectional Study","volume":"5","author":"Rajajee K.","year":"2017","journal-title":"Scholars Academic Journal of Biosciences"},{"issue":"1","key":"e_1_2_8_12_1","first-page":"15","article-title":"Investigation of Periodontal Parameters, Total Antioxidant Status and Ferritin Levels in Patients With Thalassemia Major","volume":"8","author":"Gunay A.","year":"2015","journal-title":"Journal of International Dental and Medical 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Dental Health Status in Major Thalassemia Patients Referred to Ahvaz Shafa Hospital","author":"Jahangirnezhad M.","year":"2014","journal-title":"Jundishapur Scientific Medical Journal"},{"issue":"1","key":"e_1_2_8_22_1","first-page":"81","article-title":"Dental and Periodontal Condition in Patients Affected by \u03b2\u2010Thalassemia Major and \u03b2\u2010Thalassemia Intermedia: A Study Among Adults in Sicily, Italy","volume":"3","author":"Pedull\u00e0 E.","year":"2015","journal-title":"Journal of Dental Health, Oral Disorders & Therapy"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3182025058"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40510-016-0120-6"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.17796\/jcpd.36.3.45763534u3n44k7w"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2015.12.008"},{"issue":"12","key":"e_1_2_8_27_1","first-page":"98","article-title":"Evaluation 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