{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:30:30Z","timestamp":1792672230130,"version":"4.5.0"},"reference-count":70,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T00:00:00Z","timestamp":1747872000000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Special Care in Dentistry"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>\n                      Tricho\u2010dento\u2010osseous syndrome (TDOS), a rare autosomal dominant condition caused by mutations in\n                      <jats:italic>DLX3<\/jats:italic>\n                      , is characterized by abnormalities in teeth, bone, and hair. This systematic review and meta\u2010analysis summarized the most frequently reported dento\u2010craniofacial features of TDOS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Searches were undertaken in five databases supplemented by manual scrutiny and a gray literature search. Observational and descriptive studies were included. Risk of bias was appraised using the Joanna Briggs Institute tools. Meta\u2010analyses of continuous, binary, and proportion data were performed, with results reported as odds ratio (OR) and 95% confidence intervals (CI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty\u2010seven studies describing 297 individuals with TDOS were included. Most studies demonstrated a low risk of bias. Taurodontism (70.5%), enamel hypoplasia (34.5%), and dental infections (28.7%) were the most prevalent dental findings. Increased bone density\/thickness (43.8%) was the primary skeletal manifestation, and sparse hair (27.2%) was the most common hair abnormality. Meta\u2010analyses revealed high odds for taurodontism (OR = 42.71; 95% CI = 7.45\u2013244.75) and consistent prevalence estimates for taurodontism (73%; 95% CI = 0.52\u20130.97) and enamel hypoplasia (71%; 95% CI = 0.52\u20130.97).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Data confirm that TDOS predominantly affects dental, skeletal, and hair structures, highlighting the need for early diagnosis, multidisciplinary care, and tailored treatment approaches.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/scd.70058","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T10:08:28Z","timestamp":1747908508000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dento\u2010Craniofacial Features of Tricho\u2010Dento\u2010Osseous Syndrome: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5270-3950","authenticated-orcid":false,"given":"Victor Zanetti","family":"Drumond","sequence":"first","affiliation":[{"name":"Department of Oral Surgery, Pathology and Clinical Dentistry, School of Dentistry Universidade Federal de Minas Gerais Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6599-3950","authenticated-orcid":false,"given":"Jos\u00e9 Alcides Almeida","family":"de Arruda","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis and Pathology, School of Dentistry Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3259-606X","authenticated-orcid":false,"given":"Bruno Augusto Benevenuto","family":"de Andrade","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis and Pathology, School of Dentistry Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5349-1091","authenticated-orcid":false,"given":"M\u00e1rcio","family":"Diniz\u2010Freitas","sequence":"additional","affiliation":[{"name":"Special Care Dentistry Unit, Medicine and Dental School, University of Santiago de Compostela Santiago de Compostela Spain"},{"name":"Medical\u2010Surgical Dentistry Research Group (OMEQUI), Health Research Institute of Santiago de Compostela (IDIS), University of Santiago de Compostela (USC) Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3207-4007","authenticated-orcid":false,"given":"Ricardo Alves","family":"Mesquita","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery, Pathology and Clinical Dentistry, School of Dentistry Universidade Federal de Minas Gerais Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2258-8071","authenticated-orcid":false,"given":"Lucas Guimar\u00e3es","family":"Abreu","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Oral Health, School of Dentistry Universidade Federal de Minas Gerais Belo Horizonte 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