{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T09:18:32Z","timestamp":1773047912715,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:00:00Z","timestamp":1749081600000},"content-version":"vor","delay-in-days":35,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Special Care in Dentistry"],"published-print":{"date-parts":[[2025,5]]},"abstract":"ABSTRACT<\/jats:title>\n \n Aim<\/jats:title>\n Actinomycosis is a chronic, suppurative, granulomatous bacterial infection caused by Actinomyces, a gram\u2010positive anaerobic bacterium commonly present on mucosal surfaces. Although not classified as an opportunistic infection, it frequently affects immunocompromised individuals.<\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n We report the case of a 54\u2010year\u2010old woman with acute myeloid leukemia who developed oral mucosal pain, odynophagia, and severe halitosis during hospitalization. Clinical examination revealed two ulcerated lesions on the hard palate, with a reported progression over three months. Computed tomography showed a perforation in the anterior maxilla. Due to severe thrombocytopenia (10\u00a0000\/mm\n 3<\/jats:sup>\n ), a biopsy was performed after platelet transfusion. The differential diagnosis initially included leukemic infiltration, oral carcinoma, and opportunistic infection. Histopathological analysis confirmed the diagnosis of actinomycosis. The patient was treated with oral Amoxicillin 1\u00a0g every 12\u00a0hours.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Diagnosing Actinomyces infections can be challenging due to their varied clinical presentations and similarity to malignant lesions. Despite its rarity, actinomycosis should be considered in the differential diagnosis of ulcerated palatal lesions, especially in immunocompromised patients.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/scd.70061","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T00:29:31Z","timestamp":1749169771000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Oral Actinomycosis in a Patient With Acute Myeloid Leukemia: A Unique Clinical Insight"],"prefix":"10.1111","volume":"45","author":[{"given":"Gabriela Barbosa","family":"Bisson","sequence":"first","affiliation":[{"name":"Department of Dentistry Central Institute Clinical Hospital of Medical School of the University of S\u00e3o Paulo S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo Baptista","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Department of Dentistry Central Institute Clinical Hospital of Medical School of the University of S\u00e3o Paulo S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osny","family":"Ferreira J\u00fanior","sequence":"additional","affiliation":[{"name":"Bauru School of Dentistry University of S\u00e3o Paulo \u2010 USP Bauru S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Paula Siqueira de Melo","family":"Peres","sequence":"additional","affiliation":[{"name":"Department of Dentistry Central Institute Clinical Hospital of Medical School of the University of S\u00e3o Paulo S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7787-4062","authenticated-orcid":false,"given":"Juliana Bertoldi","family":"Franco","sequence":"additional","affiliation":[{"name":"Department of Dentistry Central Institute Clinical Hospital of Medical School of the University of S\u00e3o Paulo S\u00e3o Paulo S\u00e3o Paulo Brazil"},{"name":"Department of Dentistry Children and Adolescent Institute Clinical Hospital of Medical School of the University of S\u00e3o Paulo S\u00e3o Paulo S\u00e3o Paulo 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