{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T16:40:07Z","timestamp":1756312807765,"version":"3.44.0"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,7,13]],"date-time":"2025-07-13T00:00:00Z","timestamp":1752364800000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Special Care in Dentistry"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>GAPO syndrome (#230740) is a rare autosomal recessive disorder characterized by growth retardation, alopecia, pseudoanodontia, and optic malformations, hence the acronym GAPO. The presence of both dentitions in the ridge leads to abnormally thick alveolar ridges, which are thought to hinder full denture fabrication and placement. This article aims to report the success of full dentures in two cases with GAPO syndrome with no surgical intervention, and we include observations from the follow\u2010ups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>Patients diagnosed with GAPO syndrome and confirmed by molecular testing were recruited from the outpatient clinic for oral rehabilitation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 3 patients, 1 male (patient 1) and 2 females (patients 2 and 3). Patient 3 failed to appear for the delivery session of her denture. The dentures of patients 1 and 2 had very good retention at the delivery sessions, and it was further enhanced during the follow\u2010ups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The undercuts present due to the ridge ballooning in GAPO patients were retentive to classical dentures. The unexpected normal muscular tone aided the retention as well. GAPO patients are compliant and motivated to be dentally rehabilitated.<\/jats:p><\/jats:sec>","DOI":"10.1111\/scd.70070","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T06:19:47Z","timestamp":1752473987000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Why Classical Dentures Are a Success in GAPO Patients?"],"prefix":"10.1111","volume":"45","author":[{"given":"Mohamed A.","family":"Abdel\u2010Kader","sequence":"first","affiliation":[{"name":"Oro\u2010Dental Genetics Department Human Genetics &amp; Genome Research Institute, National Research Centre  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mostafa I.","family":"Mostafa","sequence":"additional","affiliation":[{"name":"Oro\u2010Dental Genetics Department Human Genetics &amp; Genome Research Institute, National Research Centre  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mennat","family":"Mehrez","sequence":"additional","affiliation":[{"name":"Oro\u2010Dental Genetics Department Human Genetics &amp; Genome Research Institute, National Research Centre  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320190202"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2013.03.023"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320370210"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320510303"},{"key":"e_1_2_8_6_1","article-title":"GAPO Syndrome With Pansutural Craniosynostosis Leading to Intracranial Hypertension","volume":"2014","author":"Goyal N.","year":"2014","journal-title":"Case Reports"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.35734"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/13697137.2016.1200551"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.35992"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36440"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2017.12.002"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0103-64402006000300016"},{"issue":"4","key":"e_1_2_8_13_1","first-page":"189","article-title":"GAPO Syndrome: A New Case of This Rare Syndrome and a Review of the Relative Importance of Different Phenotypic Features in Diagnosis","volume":"19","author":"Bacon W.","year":"1999","journal-title":"Journal of Craniofacial Genetics and Developmental Biology"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.32686"},{"issue":"2","key":"e_1_2_8_15_1","first-page":"252","article-title":"EC DENTAL SCIENCE Research Article Prosthetic Rehabilitation and Cephalometric Evaluation of Gapo Syndrome: 29 Years Follow Up","volume":"18","author":"Dalkiz M.","year":"2019","journal-title":"Cronicon"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000446619"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-019-04250-9"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jds.2017.07.002"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2010.01100.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1997.tb02527.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.4103\/0976-237X.132301"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.4103\/2141-9248.181842"}],"container-title":["Special Care in Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/scd.70070","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T16:13:01Z","timestamp":1756311181000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/scd.70070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1111\/scd.70070"],"URL":"https:\/\/doi.org\/10.1111\/scd.70070","archive":["Portico"],"relation":{},"ISSN":["0275-1879","1754-4505"],"issn-type":[{"type":"print","value":"0275-1879"},{"type":"electronic","value":"1754-4505"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2025-05-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70070"}}