{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T03:52:19Z","timestamp":1785469939508,"version":"3.56.0"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Special Care in Dentistry"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Thalidomide embryopathy is a disorder associated with a wide range of congenital anomalies, including limb deformities, craniofacial abnormalities, and neurological impairments. Facial hyperalgesia and dental anxiety represent significant barriers to the safe and effective management of invasive dental procedures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>We report a 62\u2010year\u2010old woman with thalidomide embryopathy, bilateral upper limb agenesis, and pronounced facial hyperalgesia, scheduled for guided bone regeneration (GBR) as part of implant\u2010supported prosthetic treatment. Given her heightened pain sensitivity and severe dental phobia, local anesthesia alone was considered inadequate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Management and outcome<\/jats:title><jats:p>Ultrasound\u2010guided nerve block (USG\u2010NB) targeting the maxillary nerve and intravenous sedation were employed. This strategy provided targeted regional anesthesia and effective anxiolysis, enabling safe and comfortable perioperative management. The procedure was completed uneventfully. The patient reported no pain during or after the procedure, and no postoperative adverse events were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This case illustrates the utility of USG\u2010NB in managing complex dental procedures in patients with congenital disorders or pain hypersensitivity, offering insights for anesthetic management in comparable clinical situations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/scd.70074","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T05:48:42Z","timestamp":1753163322000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ultrasound\u2010Guided Nerve Block With Intravenous Moderate Sedation for Dental Surgery in Thalidomide Embryopathy With Facial Hyperalgesia"],"prefix":"10.1111","volume":"45","author":[{"given":"Aki","family":"Kawauchi","sequence":"first","affiliation":[{"name":"Department of Dental Anesthesiology Graduate School of Medical and Dental Sciences Institute of Science Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaya","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Dental Anesthesiology Graduate School of Medical and Dental Sciences Institute of Science Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asami","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Dental Anesthesiology Graduate School of Medical and Dental Sciences Institute of Science Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhiro","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Dental Anesthesiology Graduate School of Medical and Dental Sciences Institute of Science Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Dental Anesthesiology Graduate School of Medical and Dental Sciences Institute of Science Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.200900103"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/JENDSO\/BVAD114.126"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/09638288.2024.2307357"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753193418800631"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23376"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0210222"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016350802307638"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/17531934231164093"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2021.04.011"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.12543"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2015.11.009"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70068-1"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006459.PUB2\/INFORMATION\/EN"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006459.PUB3\/MEDIA\/CDSR\/CD006459\/IMAGE_N\/NCD006459\u2010CMP\u2010005\u201002.PNG"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0b013e3182405df9"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0b013e318263d396"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0b013e31825cb3d6"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0000000000000295"},{"key":"e_1_2_7_20_1","first-page":"96","article-title":"A Clinical Review and Introduction of the Diagnostic Algorithm for Thalidomide Embryopathy (DATE)","volume":"44","author":"Mansour S.","year":"2019","journal-title":"Journal of Hand Surgery"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.29.10.716"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420320118"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdrc.21096"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2016.07.015"},{"key":"e_1_2_7_25_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0155493","article-title":"Degenerative Changes in the Cervical Spine Are More Common in Middle\u2010Aged Individuals With Thalidomide Embryopathy Than in Healthy Controls","volume":"11","author":"Jahani S. 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