{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T14:02:49Z","timestamp":1776780169719,"version":"3.51.2"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"vor","delay-in-days":36,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Special Care in Dentistry"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Oral verruciform xanthoma (OVX) is an uncommon benign epithelial lesion, typically observed in otherwise healthy individuals. It has occasionally been reported in association with chronic graft\u2010versus\u2010host disease (cGVHD) following hematopoietic stem cell transplantation (HSCT). To date, only 12 cases of OVX associated with cGVHD have been reported in the literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Report<\/jats:title><jats:p>We present the first documented case of OVX in a 29\u2010year\u2010old male with Fanconi anemia (FA), occurring 19\u00a0years post\u2010HSCT. The patient initially exhibited oral leukoplakia attributed to cGVHD, followed by the development of an OVX lesion on the posterolateral tongue. Clinically, the lesion appeared as a whitish plaque with a verrucous, irregular surface and well\u2010demarcated borders. Histopathological examination revealed stratified squamous epithelium with papillary projections and keratin\u2010filled clefts, along with numerous xanthoma cells confined to the connective tissue papillae.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This case contributes to the understanding of OVX in the context of FA and cGVHD, highlighting the critical importance of accurate diagnosis and individualized management of oral lesions in this high\u2010risk population. Early recognition and intervention are essential to prevent progression and ensure optimal outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/scd.70077","type":"journal-article","created":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T05:19:05Z","timestamp":1754543945000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Oral Verruciform Xanthoma as a Manifestation of Chronic Graft\u2010Versus\u2010Host Disease in Fanconi Anemia: A Rare Case Report"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6599-3950","authenticated-orcid":false,"given":"Jos\u00e9 Alcides Almeida","family":"de Arruda","sequence":"first","affiliation":[{"name":"Department of Oral Diagnosis and Pathology, School of Dentistry Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego Belmiro do Nascimento","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis and Pathology, School of Dentistry Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3259-606X","authenticated-orcid":false,"given":"Bruno Augusto Benevenuto","family":"de Andrade","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis and Pathology, School of Dentistry Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4858-3060","authenticated-orcid":false,"given":"Thamyres Campos","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis and Pathology, School of Dentistry Universidade Federal do Rio de Janeiro  Rio de Janeiro 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Pathology, School of Dentistry Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-023-01568-4"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(71)90134-4"},{"key":"e_1_2_6_4_1","first-page":"e429","article-title":"Oral Verruciform Xanthoma: Report of 13 New Cases and Review of the Literature","volume":"23","author":"Tamiolakis P.","year":"2018","journal-title":"Medicina Oral Patologia Oral y Cirugia 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