{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T15:24:33Z","timestamp":1763047473502,"version":"3.45.0"},"reference-count":10,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T00:00:00Z","timestamp":1757808000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Special Care in Dentistry"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pediatric multisystem inflammatory syndrome (MIS\u2010C) is a rare condition associated with COVID\u201019, with few reports on its oral manifestations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Report<\/jats:title>\n                    <jats:p>\n                      A 13\u2010year\u2010old male pediatric patient with presented with fever, diarrhea, odynophagia, conjunctival hyperemia, rash, and bipalpebral edema. On physical examination, he exhibited diffuse ulcerated lesions with crusts on the vermilion border and labial mucosa, primarily affecting the labial commissures. Initially, immune\u2010mediated diseases such as erythema multiforme or Stevens\u2013Johnson syndrome were suspected, and treatment with topical corticosteroids and photobiomodulation was initiated. However, the lesions worsened, and polymerase chain reaction (PCR) testing of a sample from the lesion confirmed herpes simplex virus type 1. Given the diagnosis, corticosteroid therapy was discontinued, and decontamination using antimicrobial photodynamic therapy (methylene blue 0.01%, 5 min, 660\u00a0nm, 100\u00a0mW, 6 J\/point, energy density of 199.98 J\/cm\n                      <jats:sup>2<\/jats:sup>\n                      ) was performed. However, oral lesions and overall systemic condition worsened, and the patient died.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case highlights the need for a differential diagnosis of oral lesions in MIS\u2010C in order to carry out the most appropriate treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/scd.70082","type":"journal-article","created":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T06:32:57Z","timestamp":1757917977000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Oral Manifestations of Pediatric Multisystem Inflammatory Syndrome"],"prefix":"10.1111","volume":"45","author":[{"given":"Angela Maira","family":"Guimar\u00e3es","sequence":"first","affiliation":[{"name":"Department of Stomatology Federal University of Paran\u00e1 Curitiba Paran\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waleska Tychanowicz","family":"Kolodziejwski","sequence":"additional","affiliation":[{"name":"Department of Stomatology Federal University of Paran\u00e1 Curitiba Paran\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila Adriane","family":"Leffa","sequence":"additional","affiliation":[{"name":"Department of Stomatology Federal University of Paran\u00e1 Curitiba Paran\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscila Queiroz Mattos","family":"da Silva","sequence":"additional","affiliation":[{"name":"Department of Stomatology Federal University of Paran\u00e1 Curitiba Paran\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana Lucena","family":"Schussel","sequence":"additional","affiliation":[{"name":"Department of Stomatology Federal University of Paran\u00e1 Curitiba Paran\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa Rodrigues","family":"de Araujo","sequence":"additional","affiliation":[{"name":"Department of Stomatology Federal University of Paran\u00e1 Curitiba Paran\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431\u2010021\u201003993\u20105"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adaj.2020.11.014"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/scd.12669"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431\u2010023\u201005142\u20106"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2024.1415941"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10102105"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257\u2010024\u201000889\u20106"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.22551\/2022.37.0904.10224"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.14635"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans\u20102024\u2010056307"}],"container-title":["Special Care in Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/scd.70082","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T15:22:40Z","timestamp":1763047360000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/scd.70082"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1111\/scd.70082"],"URL":"https:\/\/doi.org\/10.1111\/scd.70082","archive":["Portico"],"relation":{},"ISSN":["0275-1879","1754-4505"],"issn-type":[{"type":"print","value":"0275-1879"},{"type":"electronic","value":"1754-4505"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"2025-05-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70082"}}