{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T15:28:03Z","timestamp":1763047683094,"version":"3.45.0"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:00:00Z","timestamp":1760918400000},"content-version":"vor","delay-in-days":49,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Special Care in Dentistry"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Despite the existence of clear management protocols for patients treated with warfarin, direct\u2010acting oral anticoagulants, and anti\u2010thrombotic medications requiring dental extractions, guidelines for patients on injectable anticoagulants or heparins are limited. This absence of advice for dentists and doctors results in potential confusion about the safety of these dental procedures, impacting timely patient care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective, observational study was completed at two Australian hospital\u2010based dental clinics to determine the frequency and severity of bleeding events, within the 48\u2010h period, following dental extractions completed in heparinized patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During the study period, 95 heparinized patients received a total of 185 dental extractions. Six patients had minor bleeding in the first 48\u00a0h after their procedure, representing a rate of 6.3%. All bleeding episodes were managed with direct pressure to the site with gauze. Bivariate analysis identified that patients treated with unfractionated heparin, compared to low\u2010molecular\u2010weight heparins, and extractions completed closer to the last dose of heparin had higher rates of post\u2010extraction bleeding (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0\u2264\u00a00.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Dental extractions can be completed safely for patients on injectable anticoagulants when careful local hemostatic measures are used. Based on the low rates and minor nature of post\u2010extraction bleeding, interruption or change to dosing of heparin therapy is unnecessary to facilitate these invasive dental procedures.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/scd.70109","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T06:19:16Z","timestamp":1761027556000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Frequency and Severity of Post\u2010Procedure Bleeding Events Following Dental Extractions Completed in Patients on Heparin Therapy"],"prefix":"10.1111","volume":"45","author":[{"given":"Claudia Patricia","family":"Lopez Silva","sequence":"first","affiliation":[{"name":"School of Dentistry The University of Queensland  Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandon","family":"Lim","sequence":"additional","affiliation":[{"name":"Melbourne Dental School University of Melbourne  Melbourne Australia"},{"name":"Dental Services, The Alfred  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pritam Daniel","family":"Sundaresan","sequence":"additional","affiliation":[{"name":"School of Allied Health The University of Western Australia  Perth Australia"},{"name":"Maxillofacial and Dental Surgery Fiona Stanley Hospital  Murdoch Australia"},{"name":"Sir John Walsh Research Institute University of Otago  Dunedin New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Oral Pathology and Special Needs Dentistry, Westmead Hospital  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathew Albert Wei Ting","family":"Lim","sequence":"additional","affiliation":[{"name":"Melbourne Dental School University of Melbourne  Melbourne Australia"},{"name":"Dental Services, The Alfred  Melbourne Australia"},{"name":"School of Translational Medicine Monash University  Melbourne Australia"},{"name":"Oral and Maxillofacial Surgery and Dental Clinic Royal Melbourne Hospital  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.126.3_suppl.188S"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/adj.12751"},{"key":"e_1_2_7_4_1","unstructured":"Expert Advisory Committee.Australian Medicines Handbook.2025 https:\/\/amhonline.amh.net.au\/."},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pmbts.2019.02.003"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-263x.2000.00180.x"},{"volume-title":"Australian Statistics on Medicines 2015","year":"2015","author":"Mabbott V.","key":"e_1_2_7_7_1"},{"volume-title":"Therapeutics Guidelines: 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