{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:18:38Z","timestamp":1787015918336,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Special Care in Dentistry"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To assess the effectiveness of prophylactic antibiotics in preventing infective endocarditis (IE) after dental procedures in pediatric patients with congenital heart disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Six electronic databases and grey literature were searched for randomized controlled trials (RCTs), case\u2010control studies, and cohort studies in pediatric patients who received antibiotic prophylaxis (AP) before any dental procedure compared to pediatric patients undergoing the same procedures without AP to prevent IE and\/or bacteremia. The Newcastle\u2013Ottawa scale was used to evaluate the internal validity of the included studies. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) was used to assess the certainty of evidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      1774 studies were screened after duplicate removal. Three case\u2010control studies met the inclusion criteria and were included. One study evaluated IE as an outcome, whereas the other two studies evaluated bacteremia after dental procedures. Meta\u2010analysis could not be conducted for IE, whereas pooling results were attempted for two studies evaluating bacteremia as an outcome. The odds of IE after a dental procedure within the last 6 months with AP were higher than without AP (Odds ratio: 3.44, 95% CI: 0.93, 12.65,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.06) in the only study. However, AP was effectively able to reduce bacteremia after dental procedures in two studies that evaluated bacteremia (Pooled odds ratio: 0.24, 95% CI: 0.14, 0.42,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The GRADE evidence was very low to conclude that prophylactic antibiotics might have a role in preventing IE or bacteremia in children with congenital cardiac diseases due to insufficient studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/scd.70112","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T13:52:48Z","timestamp":1763733168000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prophylactic Antibiotics for Prevention of Infective Endocarditis or Bacteremia in Pediatric Patients With Congenital Heart Disease Undergoing Dental Procedures: Systematic Review"],"prefix":"10.1111","volume":"45","author":[{"given":"Cameron","family":"Loper","sequence":"first","affiliation":[{"name":"DDS Candidate, College of Dentistry Oklahoma University Health Sciences Center (OUHSC)  Oklahoma City Oklahoma USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1790-4076","authenticated-orcid":false,"given":"Jordan","family":"Baskette","sequence":"additional","affiliation":[{"name":"DDS Candidate, College of Dentistry Oklahoma University Health Sciences Center (OUHSC)  Oklahoma City Oklahoma USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4595-0611","authenticated-orcid":false,"given":"Timothy R.","family":"Fagan","sequence":"additional","affiliation":[{"name":"William E. Brown Chair in Dentistry Department of Developmental Sciences College of Dentistry Oklahoma University Health Sciences Center (OUHSC)  Oklahoma City Oklahoma USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6486-5893","authenticated-orcid":false,"given":"Divesh","family":"Sardana","sequence":"additional","affiliation":[{"name":"Assistant Professor, Department of Pediatric Dentistry Indiana University School of Dentistry, and James Whitcomb Riley Hospital for Children  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.14531"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13957"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.artd.2015.12.003"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2021.01.051"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/23800844211020272"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.42987"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.7150\/jbji.40096"},{"key":"e_1_2_10_9_1","unstructured":"\"Clinical Guideline [CG64]. Prophylaxis against infective endocarditis: antimicrobial prophylaxis against infective endocarditis in adults and children undergoing interventional procedures \" Last accessed March 6 2025 Published2008 Updated: 2016. Available at:https:\/\/www.nice.org.uk\/guidance\/cg64."},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(14)62007\u20109"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.22\u20100580"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.3909"},{"key":"e_1_2_10_13_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 6.5 (updated August 2024)","author":"Higgins J. P. T.","year":"2024"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2700"},{"key":"e_1_2_10_15_1","unstructured":"G. A.Wells B.Shea D.O'Connell et\u00a0al. The Newcastle\u2010Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta\u2010Analyses Last accessed October 14 2024 Available at:https:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp."},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.08.009"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.43.230.451"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345900690101201"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.04.026"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010\u2010022\u201001900\u20100"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl\u20102015\u2010309102"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2022.07.012"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2024.0873"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.022047"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijdr.ijdr_810_21"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adaj.2019.06.017"}],"container-title":["Special Care in Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/scd.70112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T13:10:30Z","timestamp":1767359430000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/scd.70112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1111\/scd.70112"],"URL":"https:\/\/doi.org\/10.1111\/scd.70112","archive":["Portico"],"relation":{},"ISSN":["0275-1879","1754-4505"],"issn-type":[{"value":"0275-1879","type":"print"},{"value":"1754-4505","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"2025-05-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70112"}}