{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T17:51:28Z","timestamp":1775670688733,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"vor","delay-in-days":47,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Special Care in Dentistry"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The aim of this study is to characterize the clinical and microscopic features of recurrent oral\/labial HSV\u20101 infection with unusual clinical presentations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A literature review and retrospective case series of patients with recurrent oral\/labial HSV\u20101 with unusual presentations were conducted. Data were collected from medical records, and all cases were confirmed by histopathology and immunohistochemistry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eight patients (five males, 62.5%; three females, 37.5%) with a mean age of 61.8 years presented with unusual HSV\u20101 manifestations, including solitary lesions, white plaque\u2010like appearance, non\u2010keratinized site involvement, or prolonged duration. Lesions involved the tongue border (\n                      <jats:italic>n<\/jats:italic>\n                      = 4, 50%), anterior ventral tongue, hard palate, posterior ridge crest, and lower lip (\n                      <jats:italic>n<\/jats:italic>\n                      = 1, 12.5% each). Presented as well\u2010demarcated solitary ulcers (\n                      <jats:italic>n<\/jats:italic>\n                      = 6, 75%), solitary papule (\n                      <jats:italic>n<\/jats:italic>\n                      = 1, 12.5%), and whitish plaque\u2010like lesions (\n                      <jats:italic>n<\/jats:italic>\n                      = 1, 12.5%). Only two patients were immunosuppressed. All cases responded successfully to management, including pharmacotherapy, surgical excision, or photobiomodulation. Unusual clinical presentations of oral\/labial HSV\u20101 infection are scarcely reported in the literature.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Unusual HSV\u20101 manifestations can occur in immunocompetent individuals; however, exclusion of undiagnosed immunosuppression remains necessary. A definitive diagnosis relies on careful histopathological evaluation of ulcer edges, which is crucial for guiding appropriate treatment.\u00a0Further documentation of similar cases is essential to reinforce that these unusual presentations can indeed affect immunocompetent patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/scd.70129","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T05:42:13Z","timestamp":1766122933000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Unusual Oral Presentations of Herpes Simplex Virus\u20101: A Series of Eight Cases and Literature Review"],"prefix":"10.1111","volume":"45","author":[{"given":"Jo\u00e3o Paulo Gon\u00e7alves","family":"de Paiva","sequence":"first","affiliation":[{"name":"Oral Diagnosis Department Faculdade De Odontologia de Piracicaba Universidade Estadual de Campinas (FOP\u2010UNICAMP)  Piracicaba S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebasti\u00e3o Silv\u00e9rio","family":"Sousa\u2010Neto","sequence":"additional","affiliation":[{"name":"Oral Diagnosis Department Faculdade De Odontologia de Piracicaba Universidade Estadual de Campinas (FOP\u2010UNICAMP)  Piracicaba S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurilo Ant\u00f4nio Correia","family":"Humberto","sequence":"additional","affiliation":[{"name":"Oral Medicine in Private Practice  Pirassununga S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5060-7738","authenticated-orcid":false,"given":"Marco Ant\u00f4nio de Oliveira","family":"Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"Oral Pathology &amp; Oral Medicine Faculty of Dentistry University of Toronto  Toronto Ontario Canada"},{"name":"Department of Dental and Maxillofacial Sciences Sunnybrook Health Sciences Centre  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7641-0320","authenticated-orcid":false,"given":"Justin","family":"Bubola","sequence":"additional","affiliation":[{"name":"Oral Pathology &amp; Oral Medicine Faculty of Dentistry University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Narciso Rosa","family":"Assun\u00e7\u00e3o J\u00fanior","sequence":"additional","affiliation":[{"name":"Servi\u00e7o De Estomatologia Hospital Santa Casa Da Miseric\u00f3rdia de Santos. Servi\u00e7o de Estomatologia, Hospital Infantil Gonzaga  Santos S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo","family":"Marcucci","sequence":"additional","affiliation":[{"name":"Stomatology and Oral and Maxillofacial Surgery Center, Hospital Heli\u00f3polis, S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcondes","family":"Sena\u2010Filho","sequence":"additional","affiliation":[{"name":"Oral Surgery and Oral Medicine in Private Practice  Goi\u00e2nia Goi\u00e1s Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celso Augusto","family":"Lemos","sequence":"additional","affiliation":[{"name":"Departament of Oral Medicine School of Dentistry University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Saldivia\u2010Siracusa","sequence":"additional","affiliation":[{"name":"Oral Diagnosis Department Faculdade De Odontologia de Piracicaba Universidade Estadual de Campinas (FOP\u2010UNICAMP)  Piracicaba S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2040-6617","authenticated-orcid":false,"given":"Alan Roger","family":"Santos\u2010Silva","sequence":"additional","affiliation":[{"name":"Oral Diagnosis Department Faculdade De Odontologia de Piracicaba Universidade Estadual de Campinas (FOP\u2010UNICAMP)  Piracicaba S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacks","family":"Jorge","sequence":"additional","affiliation":[{"name":"Oral Diagnosis Department Faculdade De Odontologia de Piracicaba Universidade Estadual de Campinas (FOP\u2010UNICAMP)  Piracicaba S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1840-4911","authenticated-orcid":false,"given":"Pablo Agustin","family":"Vargas","sequence":"additional","affiliation":[{"name":"Oral Diagnosis Department Faculdade De Odontologia de Piracicaba Universidade Estadual de Campinas (FOP\u2010UNICAMP)  Piracicaba S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,18]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268823000183"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2023.1118249"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2024.110652"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy562"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-37833-8"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2019.07.012"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2007.00586.x"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.14635"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13234"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.35699\/2178-1990.2023.44990"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.5935\/2525-5711.20190025"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/v11050463"},{"key":"e_1_2_14_14_1","first-page":"96","article-title":"Immunohistochemistry Is Rarely Justified for the Diagnosis of Viral Infections","volume":"147","author":"Solomon I. 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