{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T08:08:32Z","timestamp":1779264512823,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"vor","delay-in-days":49,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Special Care in Dentistry"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Oral mucositis (OM) is a potentially severe side effect of oncological treatment. This study aimed to conduct a comprehensive scoping review of extraoral photobiomodulation (EOPBM) in the treatment or prevention of OM in oncologic patients. Studies were categorized according to the Oxford Centre for Evidence\u2010Based Medicine (OCEBM) recommendations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A search was conducted in three databases for comparative or non\u2010comparative studies. There were no language or publication year restrictions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The review included nine studies, with varying levels of evidence. Three studies were categorized as OCEBM level 2, and six as level 4. While EOPBM offered advantages, such as shorter session durations and potentially more accessible light application, the review found limited evidence for its exclusive use in preventing or treating OM. It included a single randomized controlled trial (RCT) comparing EOPBM with IOPBM, which found no significant differences between the groups in OM development or severity. Additionally, studies comparing EOPBM with sham sessions, placebo, or no treatment yielded mixed results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>EOPBM shows promise in preventing OM in oncological patients, with some advantages such as shorter session durations. However, the current level of evidence for exclusive EOPBM protocols remains limited.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/scd.70145","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T05:34:14Z","timestamp":1771565654000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Critical Scoping Review of Extraoral Photobiomodulation for Oral Mucositis in Oncological Patients"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6826-0798","authenticated-orcid":false,"given":"Joao L. G. C.","family":"Monteiro","sequence":"first","affiliation":[{"name":"Department of Medicine Harvard Medical School Brigham and Women's Hospital Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoela D.","family":"Martins","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology School of Dentistry Universidade Federal do Rio Grande Do Sul Porto Alegre Rio Grande do Sul Brazil"},{"name":"Department of Oral Medicine Hospital De Cl\u00ednicas de Porto Alegre (HCPA\/UFRGS) Porto Alegre Rio Grande do Sul Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5596-7222","authenticated-orcid":false,"given":"Nathaniel S.","family":"Treister","sequence":"additional","affiliation":[{"name":"Division of Oral Medicine and Dentistry Brigham and Women's Hospital Boston Massachusetts USA"},{"name":"Department of Oral Medicine Infection and Immunity, Harvard School of Dental Medicine Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8554-8849","authenticated-orcid":false,"given":"Fernando P. S.","family":"Guastaldi","sequence":"additional","affiliation":[{"name":"Division of Oral and Maxillofacial Surgery Department of Surgery Massachusetts General Hospital Boston Massachusetts USA"},{"name":"Department of Oral and Maxillofacial Surgery Harvard School of Dental Medicine  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2017.00089"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21704"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21704"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.disamonth.2021.101300"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.4356"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.24905"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol28040250"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010016\u20103152\u2010z"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcped.2019.05.012"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2016.01.005"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/froh.2021.689386"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/1364557032000119616"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.7326\/M18\u20100850"},{"key":"e_1_2_7_15_1","unstructured":"OCEBM Levels of Evidence Working Group. The Oxford Levels of Evidence 2 [Internet]. Oxford Centre for Evidence\u2010Based Medicine; [cited 2026 Feb 3] https:\/\/www.cebm.ox.ac.uk\/resources\/levels\u2010of\u2010evidence\/ocebm\u2010levels\u2010of\u2010evidence."},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010021\u201006625\u20108"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010021\u201006228\u20103"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.20453\/reh.v31i3.4046"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1134\/S1054660X09170150"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1089\/104454702320901107"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010011\u20101223\u20108"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjspcare\u20102019\u2010001851"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2015.4021"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010023\u201008243\u2010y"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1089\/photob.2023.0091"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omsc.2021.100208"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.927685"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11122207"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010019\u201004890\u20102"}],"container-title":["Special Care in Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/scd.70145","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/scd.70145","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/scd.70145","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T07:23:15Z","timestamp":1779261795000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/scd.70145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/scd.70145"],"URL":"https:\/\/doi.org\/10.1111\/scd.70145","archive":["Portico"],"relation":{},"ISSN":["0275-1879","1754-4505"],"issn-type":[{"value":"0275-1879","type":"print"},{"value":"1754-4505","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2024-10-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70145"}}