{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:48:36Z","timestamp":1777942116408,"version":"3.51.4"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Special Care in Dentistry"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To summarize the evidence on the association of oral candidiasis with solid organ transplantation in case\u2010control and cohort studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The quality of studies was assessed using the Newcastle\u2013Ottawa scale. Random\u2010effects restricted maximum likelihood model or Fixed\u2010effects Mantel\u2013Haenszel models were used to pool the results appropriately, and sensitivity analysis, subgroup analysis, and publication bias were assessed. The certainty of evidence was assessed using the GRADE approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The pooled OR of candidiasis in immunosuppressed individuals receiving solid organ transplants compared to controls was found to be 3.52 (95% CI: 1.92, 6.46;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). The pooled OR of oral candidiasis in kidney transplant recipients compared to controls was 3.53 (95% CI: 1.92, 6.49;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05); for liver, 20.12 (95% CI: 3.83, 105.74;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00\u00a0.05), and heart, 152.01 (95% CI: 17.71, 1304.96;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>There was moderate certainty of evidence that there was an increased risk of oral candidiasis in immunosuppressed patients who received solid organ transplants compared to healthy controls. Similarly, the evidence was moderate for subgroup analysis regarding the kidney transplant recipients, liver transplant recipients, and heart transplant recipients. Due to the lack of current research, future research should evaluate the risk of oral candidiasis in patients receiving pancreas or small bowel transplants. Also, future studies should evaluate the role of prophylactic antifungals in immunosuppressed solid organ transplant recipients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>PROSPERO number: CRD42022363816.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/scd.70157","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T12:40:56Z","timestamp":1774269656000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Solid Organ Transplantation and Oral Candidiasis: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"46","author":[{"given":"Neha","family":"Shah","sequence":"first","affiliation":[{"name":"Department of Oral Pathology Guru Nanak Institute of Dental Sciences and Research (GNIDSR)  Kolkata West Bengal India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sangeeta","family":"Sinha","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology Guru Nanak Institute of Dental Sciences and Research (GNIDSR)  Kolkata West Bengal India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhay","family":"Sonthalia","sequence":"additional","affiliation":[{"name":"Private Practitioner  Kolkata West Bengal India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6486-5893","authenticated-orcid":false,"given":"Divesh","family":"Sardana","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry Indiana University School of Dentistry and James Whitcomb Riley Hospital for Children  Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,23]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"Data of the WHO\u2010ONT Global Observatory on Donation and Transplantation Accessed on June 13 2025 Weblink:https:\/\/www.transplant\u2010observatory.org\/data\u2010charts\u2010and\u2010tables\/chart\/."},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/08923973.2021.1966033"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.2481"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz1113"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1086\/651262"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3897"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13623"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02117-09"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a019778"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/20002297.2020.1820292"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2015.03.002"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034515625222"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000004871"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16935"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2024.01.005"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41415-021-3219-1"},{"key":"e_1_2_12_18_1","unstructured":"J. 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