{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:44:48Z","timestamp":1777941888318,"version":"3.51.4"},"reference-count":82,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Special Care in Dentistry"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Periapical radiolucent lesions are commonly of endodontic origin; however, some persistent cases may indicate non\u2010endodontic pathologies, including malignancies. Diffuse large B\u2010cell lymphoma (DLBCL) is the most prevalent subtype of lymphoma affecting the oral and maxillofacial region, yet its primary occurrence in the jaws is rare. This case report highlights the diagnostic challenges in differentiating endodontic lesions from periapical lymphomas and includes a literature review of documented cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Report<\/jats:title>\n                    <jats:p>A 44\u2010year\u2010old male presented with a persistent periapical lesion in the anterior maxilla, unresponsive to endodontic and periodontal treatments. Clinical examination revealed facial asymmetry, gingival edema, palatal swelling, and dental mobility. Imaging showed an ill\u2010defined hypodense lesion extending beyond the periapical region. Fine needle aspiration and incisional biopsy confirmed DLBCL through histopathology and immunohistochemistry. The patient underwent six cycles of R\u2010CHOP chemotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After treatment, intraoral examination revealed mucosal integrity, absence of swelling, and stabilization of dental mobility. Cone\u2010beam computed tomography demonstrated bone regeneration, and PET\/CT imaging confirmed complete remission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case underscores the importance of considering malignancies in the differential diagnosis of persistent periapical lesions. Accurate clinicoradiographic assessment, histopathological confirmation, and interdisciplinary collaboration are essential for timely diagnosis and improved patient outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/scd.70162","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T09:08:49Z","timestamp":1774602529000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intraosseous Non\u2010Hodgkin Lymphoma Mimicking a Periapical Lesion"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1357-4129","authenticated-orcid":false,"given":"Laryssa Thain\u00e1 Mello Queiroz","family":"Cunha","sequence":"first","affiliation":[{"name":"Department of Oral Diagnosis, Stomatology and Oral Pathology Areas, Piracicaba Dental School State University of Campinas (UNICAMP), Piracicaba  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7640-0719","authenticated-orcid":false,"given":"Joab Cabral","family":"Ramos","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis, Stomatology and Oral Pathology Areas, Piracicaba Dental School State University of Campinas (UNICAMP), Piracicaba  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7542-476X","authenticated-orcid":false,"given":"Isabel Schausltz Pereira","family":"Faustino","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Public Health and Legal Dentistry University of Sao Paulo (USP), Ribeir\u00e3o Preto  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2711-3147","authenticated-orcid":false,"given":"Silvia Maria Paparotto","family":"Lopes","sequence":"additional","affiliation":[{"name":"Private Dental Practice, Piracicaba  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2040-6617","authenticated-orcid":false,"given":"Alan Roger","family":"Santos\u2010Silva","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis, Stomatology and Oral Pathology Areas, Piracicaba Dental School State University of Campinas (UNICAMP), Piracicaba  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1840-4911","authenticated-orcid":false,"given":"Pablo Agustin","family":"Vargas","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis, Stomatology and Oral Pathology Areas, Piracicaba Dental School State University of Campinas (UNICAMP), Piracicaba  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rcio Ajudarte","family":"Lopes","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis, Stomatology and Oral Pathology Areas, Piracicaba Dental School State University of Campinas (UNICAMP), Piracicaba  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.4317\/jced.57957"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.14744\/eej.2020.42714"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2020.08.023"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2024.11.005"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jormas.2020.01.006"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2020.01.003"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2017.04.001"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030\u20104220(84)90183\u2010X"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030\u20104220(88)90099\u20100"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930390109"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099\u20102399(89)80179\u20107"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030\u20104220(90)90216\u2010F"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0278\u20102391(90)90442\u20105"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1995.0002"},{"key":"e_1_2_10_16_1","first-page":"175","article-title":"Malignant Lymphoma Presenting as Periapical Pathology: A Report of Two Cases","volume":"38","author":"Mopsik E. 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