{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:45:00Z","timestamp":1777941900920,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":50,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Special Care in Dentistry"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the safety and efficacy of a conscious intramuscular (IM) sedation protocol combined with inhalational sedation in children with autism spectrum disorder (ASD) undergoing outpatient dental treatment, based on clinical data and dentists\u2019 perceptions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Thirty\u2010seven sedation appointments in 28 patients with ASD were analyzed. Patients received an IM protocol of midazolam 0.1\u00a0mg\/kg, ketamine 0.7\u00a0mg\/kg, dexmedetomidine 0.5 mcg\/kg, and promethazine 0.3\u00a0mg\/kg. Data collection included demographics, support needs, use of central nervous system (CNS) depressants, procedures performed, adverse events, sedation time, clinicians\u2019 assessments, and vital signs. Most patients were males (68%); aged 3\u201312 years and 65% required Level III support. CNS depressants were routinely used in 66% of cases. Surgical procedures occurred in 46% of appointments, and mean sedation time was 40 min. Only five (14%) adverse events were observed, and clinicians rated sedation as excellent in 62% of cases. Vital signs showed minimal variation throughout sedation. No statistically significant association were found between CNS depressant use and adverse events or between sedation success and sex, age, support level, or procedure characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This IM sedation protocol appears safe and effective for outpatient dental care in individuals with ASD. Further research is needed to expand equitable access to sedation\u2010based care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/scd.70171","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T09:37:50Z","timestamp":1776677870000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of Conscious Intramuscular Sedation in Children With Autism Spectrum Disorder Undergoing Outpatient Dental Treatment: A Retrospective Observational Cross\u2010Sectional Study"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7592-1785","authenticated-orcid":false,"given":"Bruna Lavinas Sayed","family":"Picciani","sequence":"first","affiliation":[{"name":"Postgraduate Program in Dentistry, Health Institute of Nova Friburgo Fluminense Federal University  Nova Friburgo RJ Brazil"},{"name":"Graduate Program in Dentistry, Health Institute of Nova Friburgo Fluminense Federal University  Nova Friburgo RJ Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro Fernandes de Souza","family":"Lima","sequence":"additional","affiliation":[{"name":"Graduate Program in Dentistry, Health Institute of Nova Friburgo Fluminense Federal University  Nova Friburgo RJ Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nat\u00e1lia Cristina Ruy","family":"Carneiro","sequence":"additional","affiliation":[{"name":"Graduate Program in Dentistry, Faculdade Anhanguera Unidade Timbiras  Belo Horizonte MG Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Breno Maia Mariz","family":"Plaisant","sequence":"additional","affiliation":[{"name":"Graduate Program in Dentistry, Health Institute of Nova Friburgo Fluminense Federal University  Nova Friburgo RJ Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milena Tissi Fonseca","family":"Vieira","sequence":"additional","affiliation":[{"name":"Graduate Program in Dentistry, Health Institute of Nova Friburgo Fluminense Federal University  Nova Friburgo RJ Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lais David","family":"Amaral","sequence":"additional","affiliation":[{"name":"Graduate Program in Dentistry Catholic University of Bras\u00edlia  Bras\u00edlia DF Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Cristina","family":"Borges\u2010Oliveira","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Dentistry Federal University of Minas Gerais  Belo Horizonte MG Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13010059"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/joor.12724"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1362361319877337"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/children12060750"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.5409\/wjcp.v14.i3.106778"},{"key":"e_1_2_9_7_1","first-page":"358","volume-title":"The Reference Manual of Pediatric Dentistry","author":"American Academy of Pediatric Dentistry","year":"2024"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1186823"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.17245\/jdapm.2020.20.1.1"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10005-1807"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.4103\/1735-3327.245235"},{"key":"e_1_2_9_12_1","article-title":"Sedation and Its Potencial Risks in Children With Autism Spectrum due to Drug Overlaps: A Critical Review","volume":"24","author":"Alonso H. 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