{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T13:10:47Z","timestamp":1789996247313,"version":"4.0.1"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Special Care in Dentistry"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Drug\u2010induced gingival overgrowth (DIGO) is a well\u2010recognized adverse effect associated with several systemic medications, including calcium channel blockers such as amlodipine. Management becomes particularly challenging in medically complex patients requiring continuous anticoagulant and antiplatelet therapy, in which conventional surgical approaches may increase the risk of perioperative bleeding.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>We report the case of a 66\u2010year\u2010old male patient with severe, multifocal amlodipine\u2010induced gingival overgrowth associated with generalized severe periodontitis (Stage IV) and a complex cardiovascular history, including previous ischemic strokes. The patient was under long\u2010term anticoagulant and antiplatelet therapy (acenocoumarol adjusted to therapeutic INR and acetylsalicylic acid 100\u00a0mg\/day), as well as amlodipine 10\u00a0mg\/day and other cardiovascular medications. Following interdisciplinary evaluation, amlodipine was discontinued, while antithrombotic therapy was maintained due to the patient's high cardiovascular risk. After initial periodontal therapy and partial lesion regression, persistent fibrotic gingival enlargements were surgically excised using a diode laser (810\u2013980\u00a0nm) without interruption of antithrombotic medication.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Laser\u2010assisted excision was performed uneventfully, providing excellent hemostatic control with no intraoperative or postoperative bleeding and without the need for sutures. Histopathological examination confirmed the diagnosis of DIGO. Complete healing was observed at the 15\u2010day follow\u2010up, with no recurrence or complications. Potential risks associated with laser use, such as thermal damage to adjacent tissues, were minimized through appropriate parameter selection and surgical technique.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case highlights the usefulness of diode laser surgery as a safe and effective therapeutic option for the management of severe DIGO in patients requiring continuous antithrombotic therapy. Its excellent hemostatic properties and minimal invasiveness make it particularly valuable in special care dentistry and in interdisciplinary management of high\u2010risk cardiovascular patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/scd.70177","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T07:03:36Z","timestamp":1778137416000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Laser\u2010Assisted Management of Amlodipine\u2010Induced Gingival Overgrowth in a Medically Complex Patient"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5201-1444","authenticated-orcid":false,"given":"Gerardo","family":"Gilligan","sequence":"first","affiliation":[{"name":"Oral Medicine Department Facultad De Odontolog\u00eda Universidad Nacional de C\u00f3rdoba  C\u00f3rdoba Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7852-0804","authenticated-orcid":false,"given":"Pedro","family":"Benavides","sequence":"additional","affiliation":[{"name":"Oral Medicine Department Facultad De Odontolog\u00eda Universidad Nacional de C\u00f3rdoba  C\u00f3rdoba Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7263-1886","authenticated-orcid":false,"given":"Juan Cruz","family":"Romero\u2010Panico","sequence":"additional","affiliation":[{"name":"Oral Medicine Department Facultad De Odontolog\u00eda Universidad Nacional de C\u00f3rdoba  C\u00f3rdoba Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8639-2057","authenticated-orcid":false,"given":"Federico","family":"Garola","sequence":"additional","affiliation":[{"name":"Oral Medicine Department Facultad De Odontolog\u00eda Universidad Nacional de C\u00f3rdoba  C\u00f3rdoba Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0762-6036","authenticated-orcid":false,"given":"Ana Clara","family":"Casadoumecq","sequence":"additional","affiliation":[{"name":"Laser Unit Facultad De Odontolog\u00eda Universidad De Buenos Aires  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24065448"},{"issue":"6","key":"e_1_2_10_3_1","first-page":"E480","article-title":"Amlodipine\u2010induced Gingival Hyperplasia","volume":"11","author":"Lafzi A.","year":"2006","journal-title":"Medicina oral, patologia oral y cirugia bucal"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2025.07.016"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.033780"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111783"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.37349\/emed.2025.1001325"},{"issue":"12","key":"e_1_2_10_8_1","article-title":"Laser\u2010Assisted Gingivectomy in Amlodipine\u2010Induced Gingival Enlargement: a Case Report","volume":"16","author":"Kaliyaperumal R.","year":"2024","journal-title":"Cureus"},{"issue":"12","key":"e_1_2_10_9_1","article-title":"Treatment of Gingival Growth due to Amlodipine Use With a 445\u2010nm Diode Laser: a Case Report","volume":"14","author":"Okumu\u015f \u00d6. F.","year":"2022","journal-title":"Cureus"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2015.05.015"},{"issue":"5","key":"e_1_2_10_11_1","first-page":"15","article-title":"Diode Laser Assisted Excision of Gingival Fibroma: a Case Report","volume":"14","author":"Sarkar S.","year":"2022","journal-title":"Heal Talk"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.47162\/RJME.66.3.20"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1991.tb01698.x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.00930.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.32793\/jida.v7i1.1124"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.37349\/emed.2025.1001325"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-024-04364-w"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.22.12.121602"}],"container-title":["Special Care in Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/scd.70177","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/scd.70177","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/scd.70177","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:47:09Z","timestamp":1789994829000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/scd.70177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/scd.70177"],"URL":"https:\/\/doi.org\/10.1111\/scd.70177","archive":["Portico"],"relation":{},"ISSN":["0275-1879","1754-4505"],"issn-type":[{"value":"0275-1879","type":"print"},{"value":"1754-4505","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2026-01-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70177"}}