{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T13:10:25Z","timestamp":1789996225013,"version":"4.0.1"},"reference-count":85,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Special Care in Dentistry"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Clinical signs observed during head and neck examination offer important diagnostic clues. This scoping review aimed to identify key clinical signs in this region associated with diseases and syndromes and to map them according to their location.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An electronic literature search was performed in five databases (Embase, LILACS, PubMed, Scopus, and Web of Science) and in grey literature (Google Scholar and ProQuest). Studies were excluded if they did not involve humans, addressed non\u2010specific or non\u2013head and neck signs, used auxiliary equipment during examination, were conducted outside clinical settings, lacked original data, or had no accessible full text. Clinical signs were categorized as ocular, cutaneous, intraoral, auricular, or other.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 54 studies met the criteria, identifying 43 distinct clinical signs. Intraoral signs were the most frequent (\n                      <jats:italic>n<\/jats:italic>\n                      = 15), with \u201cstrawberry tongue\u201d being the most common. Cutaneous signs (10) included caf\u00e9\u2010au\u2010lait lesions, facial trichilemmomas, and Pemberton's sign. Ocular manifestations appeared in nine cases, with Horner's syndrome being the most reported. Other signs accounted for six reports, and auricular signs (three) were the least frequent, with Frank's sign most cited.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This review underscores the diagnostic relevance of head and neck clinical signs as indicators of systemic diseases, including intraoral ulcers, caf\u00e9\u2010au\u2010lait macules, Kayser\u2010Fleischer rings, Frank's sign, malar rash, and port\u2010wine stains.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/scd.70185","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T04:45:36Z","timestamp":1778820336000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Head and Neck Clinical Signs Associated With Diseases: A Scoping Review"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7613-3465","authenticated-orcid":false,"given":"Helena Miguel","family":"Cotter","sequence":"first","affiliation":[{"name":"Department of Dentistry Federal University of Santa Catarina  Florian\u00f3polis Santa Catarina Brazil"},{"name":"Oral Diagnosis Department, Piracicaba Dental School University of Campinas  Piracicaba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8338-3857","authenticated-orcid":false,"given":"Mateus Jos\u00e9","family":"Dutra","sequence":"additional","affiliation":[{"name":"Oral Diagnosis Department, Piracicaba Dental School University of Campinas  Piracicaba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9511-5078","authenticated-orcid":false,"given":"Gustavo Davi","family":"Rabelo","sequence":"additional","affiliation":[{"name":"Department of Dentistry Federal University of Santa Catarina  Florian\u00f3polis Santa Catarina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0127-7998","authenticated-orcid":false,"given":"Ana Carolina Prado","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Oral Diagnosis Department, Piracicaba Dental School University of Campinas  Piracicaba S\u00e3o Paulo Brazil"},{"name":"S\u00e3o Paulo State Cancer Institute S\u00e3o Paulo University Medical School  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcio Ajudarte","family":"Lopes","sequence":"additional","affiliation":[{"name":"Oral Diagnosis Department, Piracicaba Dental School University of Campinas  Piracicaba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5349-1091","authenticated-orcid":false,"given":"M\u00e1rcio","family":"Diniz\u2010Freitas","sequence":"additional","affiliation":[{"name":"Medical\u2010Surgical Dentistry Research Group (OMEQUI), Health Research Institute of Santiago de Compostela (IDIS) University of Santiago de Compostela (USC)  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0481-156X","authenticated-orcid":false,"given":"Luiz Paulo","family":"Kowalski","sequence":"additional","affiliation":[{"name":"AC Camargo Cancer Center  S\u00e3o Paulo S\u00e3o Paulo Brazil"},{"name":"Department of Head and Neck Surgery, School of Medicine, Hospital Das Cl\u00ednicas University of S\u00e3o Paulo (HC\u2010FMUSP)  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2040-6617","authenticated-orcid":false,"given":"Alan Roger","family":"Santos\u2010Silva","sequence":"additional","affiliation":[{"name":"Oral Diagnosis Department, Piracicaba Dental School University of Campinas  Piracicaba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7504-7597","authenticated-orcid":false,"given":"Caique Mariano","family":"Pedroso","sequence":"additional","affiliation":[{"name":"Oral Diagnosis Department, Piracicaba Dental School University of Campinas  Piracicaba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1981.tb08177.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.48.3.173"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2022.106618"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320450207"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2007.05.002"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.1982.92.6.634"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2018.06.009"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12024\u2010022\u201000463\u20108"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.2596"},{"issue":"2","key":"e_1_2_9_11_1","first-page":"61","article-title":"A Review of Clinical Signs Related to Ecchymosis","volume":"114","author":"Epperla N.","year":"2015","journal-title":"WMJ: Official Publication of the State Medical Society of Wisconsin"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.11124\/JBIES\u201020\u201000167"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2020.03.016"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.7326\/M18\u20100850"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643\u2010016\u20100384\u20104"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2022.5701"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002\u20109343(87)90229\u20104"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030\u20104220(88)90252\u20106"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr\u20102018\u2010224190"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.42855"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.2080"},{"key":"e_1_2_9_22_1","first-page":"684","article-title":"The Eye in the Marfan Syndrome","volume":"79","author":"Maumenee I. H.","year":"1981","journal-title":"Transactions of the American Ophthalmological Society"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459989310800406"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196802152780702"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459988209000504"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154\u2010016\u20109399\u20103"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105\u2010016\u20100708\u20107"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/pan.13852"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2017.04.013"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/786519"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887\u2010020\u20102019\u20100"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023\u2010020\u201001470\u20100"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18157831"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2017.10.005"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346\u20108138.2011.01333.x"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2023.08.004"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17098"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.5940"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.15744"},{"issue":"9","key":"e_1_2_9_40_1","first-page":"829","article-title":"Unilateral Facial Swelling Caused by Ramsay Hunt Syndrome Resembles Odontogenic Infection","volume":"72","author":"Jan A. M.","year":"2006","journal-title":"Journal of the Canadian Dental Association"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0165\u20105876(99)00300\u20106"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.4103\/Pigmentinternational.Pigmentinternational_58_19"},{"issue":"9","key":"e_1_2_9_43_1","first-page":"482","article-title":"Wilson's Disease: An Update","volume":"2","author":"Das S. K.","year":"2006","journal-title":"Journal of Medical Case Reports"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijd.IJD_317_17"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13256\u2010022\u201003699\u20108"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1177\/2320206819878358"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.17390"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otorri.2011.12.002"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12991"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215108002703"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2015.10.028"},{"issue":"2","key":"e_1_2_9_52_1","first-page":"451","article-title":"An Unusual Case of Traumatic Internal Carotid Artery Dissection during Snow\u2010Boarding","volume":"13","author":"Kalantzis G.","year":"2014","journal-title":"Journal of Sports Science and Medicine"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.13481\/j.1671\u2010587X.20220129"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2024.02.001"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr\u20102021\u2010242262"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1995.01890050009002"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0b013e3182a41cb5"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.31083\/j.rcm2404109"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.15787"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cdp.2007.10.014"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-5-16"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750\u20101172\u20109\u201053"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154\u2010016\u20109378\u20108"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.34172\/JEPT.2020.07"},{"key":"e_1_2_9_65_1","unstructured":"I. C. F.AmorimandR.Vieira.Dermatomiosite.2012 https:\/\/www.proquest.com\/dissertations\u2010theses\/dermatomiosite\/docview\/3086164531\/se\u20102?accountid=8113."},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.4183\/aeb.2016.227"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750\u20101172\u20107\u20104"},{"issue":"3","key":"e_1_2_9_68_1","first-page":"148","article-title":"Retrospective Analysis of 27 Patients With Cutaneous Sarcoidosis","volume":"47","author":"Aydogan K.","year":"2013","journal-title":"Turkderm"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1159\/000525798"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2007.07.201"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2008.07.014"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203319882493"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2009.09.036"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.46.3.415"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70097-0"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr\u20102019\u2010234075"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2004.02.008"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12107"},{"key":"e_1_2_9_79_1","first-page":"28","article-title":"Erysipelas and Cellulitis: A Retrospective Study of 122 Cases","volume":"100","author":"Concheiro J.","year":"2009","journal-title":"Actas dermo\u2010sifiliograficas"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214\u2010109X(21)00442\u20103"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201059426\u20104"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.zefq.2024.11.011"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.51866\/rv.37"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.07.057"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmp1508044"},{"key":"e_1_2_9_86_1","first-page":"165","article-title":"Diagnostic Error in Internal Medicine","volume":"46","author":"Graber M. L.","year":"2005","journal-title":"Archives of Internal Medicine"}],"container-title":["Special Care in Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/scd.70185","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/scd.70185","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/scd.70185","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:46:55Z","timestamp":1789994815000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/scd.70185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":85,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/scd.70185"],"URL":"https:\/\/doi.org\/10.1111\/scd.70185","archive":["Portico"],"relation":{},"ISSN":["0275-1879","1754-4505"],"issn-type":[{"value":"0275-1879","type":"print"},{"value":"1754-4505","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2026-01-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70185"}}