{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T13:10:25Z","timestamp":1789996225285,"version":"4.0.1"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":45,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Special Care in Dentistry"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the periodontal status of patients with trisomy 21 (T21) compared to non\u2010syndromic patients during orthodontic treatment with clear aligners.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The sample consisted of 30 patients, both gender, aged between 11 and 35 years, divided into two groups: T21 (\n                      <jats:italic>n<\/jats:italic>\n                      = 10, patients with T21, treated prospectively) and CONTROL (\n                      <jats:italic>n<\/jats:italic>\n                      = 20, control group, non\u2010syndromic patients). In both groups, patients were treated with Invisalign clear aligners (AlignTechnology), following the same treatment parameters. Periodontal status was assessed at five timepoints using the Gingival Bleeding Index (GBI) and the Visible Plaque Index (VPI) following the WHO criteria. Data analysis was performed with the aid of the SPSS 23.0 software, using the Shapiro\u2010Wilk test, chi\u2010square test, Fisher's exact test, Mann\u2010Whitney test, ANOVA, and t\u2010test (\u03b1 = 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Most participants were male (73.3%) and more than 21 years of age (53.3%). At baseline, the T21 group had greater periodontal pocket depth (0.20 \u00b1 0.42) than the control group (0.00 \u00b1 0.00) (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.039), but both groups reached a mean of 0.00 after 365 days (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.006). The T21 group had consistently higher VPI scores, with means of 64.82 \u00b1 16.05 at baseline and 68.35 \u00b1 18.01 at 365 days (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.000) compared to 19.15 \u00b1 13.93 and 24.61 \u00b1 17.29 in the control group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Aligners have proven to be a suitable orthodontic option for patients T21, without worsening the periodontal condition during treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/scd.70196","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:29:57Z","timestamp":1781584197000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Study of Periodontal Status in Patients With and Without Trisomy 21 During Treatment With Clear Aligners"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2285-5179","authenticated-orcid":false,"given":"Paula Vanessa Pedron","family":"Oltramari","sequence":"first","affiliation":[{"name":"Department of Orthodontics School of Dentistry Uniderp  Campo Grande Mato Grosso do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5953-4202","authenticated-orcid":false,"given":"Wericon Pedro dos","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Orthodontics School of Dentistry Uniderp  Campo Grande Mato Grosso do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1867-2126","authenticated-orcid":false,"given":"Anna Vit\u00f3ria Mendes Viana","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Oral Health For Child and Adolescent School of Dentistry Federal University of Minas Gerais  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3968-1638","authenticated-orcid":false,"given":"Saul Martins","family":"Paiva","sequence":"additional","affiliation":[{"name":"Department of Oral Health For Child and Adolescent School of Dentistry Federal University of Minas Gerais  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4342-8907","authenticated-orcid":false,"given":"Roberto","family":"Bespalez\u2010Neto","sequence":"additional","affiliation":[{"name":"Department of Orthodontics School of Dentistry Uniderp  Campo Grande Mato Grosso do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Cl\u00e1udia de Castro Ferreira","family":"Conti","sequence":"additional","affiliation":[{"name":"Department of Orthodontics School of Dentistry Uniderp  Campo Grande Mato Grosso do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4283-1051","authenticated-orcid":false,"given":"Renata Rodrigues","family":"de Almeida\u2010Pedrin","sequence":"additional","affiliation":[{"name":"Department of Orthodontics School of Dentistry Uniderp  Campo Grande Mato Grosso do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2684-0943","authenticated-orcid":false,"given":"Marcio Rodrigues","family":"de Almeida","sequence":"additional","affiliation":[{"name":"Department of Orthodontics School of Dentistry Uniderp  Campo Grande Mato Grosso do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4368-8568","authenticated-orcid":false,"given":"Thais Maria Freire","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Department of Orthodontics School of Dentistry Uniderp  Campo Grande Mato Grosso do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,15]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adaj.2018.03.010"},{"issue":"4","key":"e_1_2_11_3_1","first-page":"309","article-title":"Subgingival Periodontal Pathogens in Down syndrome Children Without Periodontal Breakdown. 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