{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T10:12:21Z","timestamp":1789035141417,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Special Care in Dentistry"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the impact of cancer treatment on the health\u2010related quality of life (HRQoL) of children and adolescents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>HRQoL self\u2010perception was assessed using the Pediatric Quality of Life Inventory 3.0 Cancer Module (PedsQL), applied to 103 children and adolescents aged 1 to 18 years, recruited from a hematology and oncology unit of a Brazil public hospital and a support house. Sociodemographic and health data were collected through structured questionnaires, and a dental examination was conducted to assess dental caries. Data were analyzed using SPSS, including descriptive and Chi\u2010square tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Most participants were male (54.4%), aged 1\u20137 years (55.3%), with a primary diagnosis of hematologic and lymphatic cancer (85.4%). Family income was up to one minimum wage (55.3%), and 70.9% of mothers had at least 8 years of education. Children aged 1\u20137 scored lower in \u201cProcedural Anxiety\u201d (45.14 \u00b1 40.37) than adolescents (66.67 \u00b1 36.30). Adolescents scored lower in \u201cNausea\u201d (55.11 \u00b1 30.06) and \u201cWorry\u201d (56.34 \u00b1 38.69) than children. HRQoL scores were associated with age (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), maternal education (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.022), brushing frequency (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.046), and decayed teeth (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.001). In the final model, self\u2010reported HRQoL among children and adolescents aged 8 to 18 years (OR = 4.28; 95% CI: 1.07\u201317.12) was associated with lower HRQoL.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Anxiety, nausea, and worry negatively impact the health\u2010related HRQoL of pediatric cancer patients, and sociodemographic factors, such as the child's age, also influence this perception, highlighting the importance of individualized and integrated approaches to care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/scd.70219","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T07:17:18Z","timestamp":1783927038000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Oncologic Treatment on Health\u2010Related Quality of Life of Children and Adolescents"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1867-2126","authenticated-orcid":false,"given":"Anna Vit\u00f3ria Mendes Viana","family":"Silva","sequence":"first","affiliation":[{"name":"Department of Oral Health For Child and Adolescent, School of Dentistry Federal University of Minas Gerais  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7817-6298","authenticated-orcid":false,"given":"Bernardo Velloso","family":"Pimenta","sequence":"additional","affiliation":[{"name":"Department of Oral Health For Child and Adolescent, School of Dentistry Federal University of Minas Gerais  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8705-361X","authenticated-orcid":false,"given":"Bruna Paula","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Department of Oral Health For Child and Adolescent, School of Dentistry Federal University of Minas Gerais  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6864-246X","authenticated-orcid":false,"given":"Alice Machado Carvalho","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Oral Health For Child and Adolescent, School of Dentistry Federal University of Minas Gerais  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0468-5863","authenticated-orcid":false,"given":"Isabel Zanforlin","family":"Freitas","sequence":"additional","affiliation":[{"name":"Department of Oral Health For Child and Adolescent, School of Dentistry Federal University of Minas Gerais  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1231-689X","authenticated-orcid":false,"given":"Matheus de Fran\u00e7a","family":"Perazo","sequence":"additional","affiliation":[{"name":"Department of Oral Health Federal University of Goias (UFG)  Goi\u00e2nia Goi\u00e1s Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3968-1638","authenticated-orcid":false,"given":"Saul Martins","family":"Paiva","sequence":"additional","affiliation":[{"name":"Department of Oral Health For Child and Adolescent, School of Dentistry Federal University of Minas Gerais  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,13]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1590\/1982\u20100275202340e200210"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0034\u201071672013000600010"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.37689\/acta\u2010ape\/2022AO0288345"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10389\u2010023\u201001982\u20106"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0104\u201007072013000300013"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/09602011.2020.1844243"},{"key":"e_1_2_12_8_1","unstructured":"I. 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