{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T12:06:36Z","timestamp":1789387596670,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Special Care in Dentistry"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aims to assess the odds ratio for acute periapical abscesses (PAs) in opioid\u2010dependent patients and compare it to non\u2010users.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data aggregated from 1\u00a0799\u00a0122 patients visiting the medical center were recorded. Data from the corresponding diagnosis codes for opioid dependence and acute PAs was retrieved by searching the appropriate query in the database. The odds ratio (OR) of acute PAs and their association with opioid dependence were calculated and analyzed statistically.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Opioid\u2010dependent patients showed significantly more acute PAs than non\u2010users. The OR for acute periapical abscesses in opioid\u2010dependent patients was 8.9. The difference in prevalence compared to the total hospital patient population was statistically significant. Following adjustment for diabetes co\u2010morbidity, the OR for acute PAs in opioid\u2010 dependent patients was 7.52, and the difference in prevalence as compared to the total hospital patient population was statistically significant. Following adjustment for smoking co\u2010morbidity, the odds ratio for acute periapical abscesses in opioid\u2010dependent patients was 3.34, and the difference in prevalence as compared to the total hospital patient population was statistically significant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Under the conditions of this study, it appears that the odds for acute periapical abscesses is significantly higher in opioid\u2010dependent patients as compared to non\u2010users.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/scd.70254","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T11:42:15Z","timestamp":1789386135000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Opioid Dependence Is Associated With Increased Odds for Acute Periapical Abscesses"],"prefix":"10.1111","volume":"46","author":[{"given":"Ilan","family":"Rotstein","sequence":"first","affiliation":[{"name":"Department of Endodontics and Periodontics University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Katz","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnostic Sciences University of Florida College of Dentistry  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,14]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Statistical Brief (Medical Expenditure Panel Survey (US))","author":"Moriya A. 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