{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T02:44:16Z","timestamp":1722912256839},"reference-count":64,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,1,11]],"date-time":"2015-01-11T00:00:00Z","timestamp":1420934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Seminars in Dialysis"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The increased frequency of cardiovascular disease observed in hemodialysis patients is secondary to the combination of many traditional (age, male sex, hypertension, smoking, diabetes mellitus, and dyslipidemia) and novel and uremia\u2010related (inflammation, uremic toxins, adipokine imbalance, coagulation disorders, protein\u2010energy wasting, volume overload, endothelial dysfunction, hyperparathyroidism, and subclinical hypothyroidism) risk factors. Usually, in the latter group, oxidative stress is included. However, after decades of research, it remains essentially unknown if oxidative stress has a causative role in the development of cardiovascular disease in long\u2010term hemodialysis patients because adequate longitudinal studies are lacking. Data deriving from cross\u2010sectional studies suggest that biomarkers of oxidative stress are associated with cardiovascular disease prevalence. Conversely, conflicting and inconclusive results have been obtained on the association between oxidative stress and coronary artery calcification, atherosclerosis, and all\u2010cause and cardiovascular disease\u2010related outcome. It is desirable that further studies are conducted on this topic in the near future.<\/jats:p>","DOI":"10.1111\/sdi.12345","type":"journal-article","created":{"date-parts":[[2015,1,12]],"date-time":"2015-01-12T01:00:46Z","timestamp":1421024446000},"page":"224-230","source":"Crossref","is-referenced-by-count":10,"title":["Wishful Thinking: The Surprisingly Sparse Evidence for a Relationship between Oxidative Stress and Cardiovascular Disease in Hemodialysis Patients"],"prefix":"10.1111","volume":"28","author":[{"given":"Maurizio","family":"Bossola","sequence":"first","affiliation":[{"name":"Hemodialysis Unit Division of Transplantation Catholic University of the Sacred Heart \u201cAgostino Gemelli\u201d University Hospital Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Tazza","sequence":"additional","affiliation":[{"name":"Hemodialysis Unit Division of Transplantation Catholic University of the Sacred Heart \u201cAgostino Gemelli\u201d University Hospital Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,1,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03670807"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfg074"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00600.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000338807"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2012.00476.x"},{"issue":"291","key":"e_1_2_11_7_1","first-page":"1997","article-title":"Oxidant and antioxidants","volume":"82","author":"Sies H","year":"1997","journal-title":"Exp Physiol"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2013.07.006"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(99)00213-0"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(98)00196-8"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-139X.2009.00659.x"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2006.08.015"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.1998.028"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1997.160"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(96)00233-X"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/14.11.2680"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2000.19086"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2001.29280"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2002.175"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00969.x"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.2005.00136.x"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-007-0486-3"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.6.1755"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005183422003"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfh217"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002059"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfl564"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(01)00610-4"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1159\/000081731"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000330"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00239.x"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2012.02.001"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2010.143"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.628875"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000035250.66458.67"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2006.01.020"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1542-4758.2011.00568.x"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1159\/000076244"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1159\/000085290"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr443"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm906"},{"key":"e_1_2_11_42_1","first-page":"54","article-title":"The relationship between carotid atherosclerosis, inflammatory cytokines, and oxidative stress in middle\u2010aged and elderly hemodialysis patients","volume":"83","author":"Ren H","year":"2013","journal-title":"Int J Nephrol"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1999.00613.x"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1159\/000057601"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.63.s84.32.x"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2006.09.004"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1159\/000100419"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.5414\/CNP68144"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1159\/000135655"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.4103\/0971-4065.75218"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.5301\/JN.2011.6442"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2011-0775"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00423.x"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/18.1.106"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfh035"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2006.03.047"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jrn.2011.10.019"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0070822"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01110113"},{"key":"e_1_2_11_60_1","article-title":"Oxidative DNA damage and mortality in hemodialysis and peritoneal dialysis patients","author":"Xu H","journal-title":"Perit Dial Int"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2011.341"},{"key":"e_1_2_11_62_1","first-page":"CD008176","article-title":"Antioxidants for chronic kidney disease","volume":"10","author":"Jun M","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_11_63_1","first-page":"31","article-title":"The effect of vitamin C supplementation and withdrawal on the mortality and morbidity of regular hemodialysis patients","volume":"31","author":"Ono K","year":"1989","journal-title":"Clin Nephrol"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02783-5"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000050628.11305.30"}],"container-title":["Seminars in Dialysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fsdi.12345","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/sdi.12345","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T03:55:24Z","timestamp":1696046124000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/sdi.12345"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,11]]},"references-count":64,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1111\/sdi.12345"],"URL":"https:\/\/doi.org\/10.1111\/sdi.12345","archive":["Portico"],"relation":{},"ISSN":["0894-0959","1525-139X"],"issn-type":[{"value":"0894-0959","type":"print"},{"value":"1525-139X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,11]]}}}