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The therapeutic use of calcimimetic agents, together with a better understanding of the pivotal role of the calcium\u2010sensing receptor (Ca<jats:styled-content style=\"fixed-case\">SR<\/jats:styled-content>) in the physiological regulation of parathyroid gland function, substantially advanced the management of hyperparathyroidism in dialysis practice. Calcimimetics bind selectively to the Ca<jats:styled-content style=\"fixed-case\">SR<\/jats:styled-content> receptor in parathyroid tissue and enhance the inhibitory effect of extracellular calcium ions on parathyroid hormone (<jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content>) secretion, thereby reducing <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> levels even when serum calcium concentrations are normal or low. The availability of calcimimetic agents for clinical use has opened a new era in the management of patients with <jats:styled-content style=\"fixed-case\">SHPT<\/jats:styled-content>. Indeed, calcimimetic compounds have been shown to reduce <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> levels and to lower serum calcium concentrations in all forms of hyperparathyroidism, including primary hyperparathyroidism (<jats:styled-content style=\"fixed-case\">PHPT<\/jats:styled-content>) and parathyroid carcinoma. Such findings underscore the critical importance of the Ca<jats:styled-content style=\"fixed-case\">SR<\/jats:styled-content> as a therapeutic target in this family of clinical disorders. New calcimimetic agents are being developed that have the potential to offer improved efficacy and safety compared with currently available calcimimetic compounds.<\/jats:p>","DOI":"10.1111\/sdi.12357","type":"journal-article","created":{"date-parts":[[2015,3,9]],"date-time":"2015-03-09T01:31:25Z","timestamp":1425864685000},"page":"497-507","source":"Crossref","is-referenced-by-count":26,"title":["The Use of Calcimimetics for the Treatment of Secondary Hyperparathyroidism: A 10 Year Evidence Review"],"prefix":"10.1111","volume":"28","author":[{"given":"Mariano","family":"Rodr\u00edguez","sequence":"first","affiliation":[{"name":"Servicio de Nefrologia IMIBIC Hospital Universitario Reina Sofia C\u00f3rdoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William G.","family":"Goodman","sequence":"additional","affiliation":[{"name":"Amgen, Inc. 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