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Consequently, oncologists, nephrologists, and pharmacists are increasingly facing challenging situations of cytotoxic drug handling in dialysis patients because of pharmacokinetic modifications. In these patients, two main issues must be considered. First, the absence of renal function in hemodialysis (<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>) patients may necessitate drug dosage reduction. Therefore, drug prescription must be cautiously checked before administration with appropriate dosage adjustment whenever necessary to ensure efficacy while avoiding overdosage and related side effects. Second, drug clearance by dialysis session must be taken into account for appropriate chemotherapy timing administration to avoid drug removal, which may result in a loss of efficacy. These two main considerations must not be considered as a contra\u2010indication to chemotherapy in <jats:styled-content style=\"fixed-case\">ESKD<\/jats:styled-content> patients, but more as a need for an individualized prescription according to available recommendations.<\/jats:p>","DOI":"10.1111\/sdi.12371","type":"journal-article","created":{"date-parts":[[2015,4,11]],"date-time":"2015-04-11T06:51:15Z","timestamp":1428735075000},"page":"413-416","source":"Crossref","is-referenced-by-count":7,"title":["Anticancer Drugs in End\u2010Stage Kidney Disease Patients"],"prefix":"10.1111","volume":"28","author":[{"given":"Nicolas","family":"Janus","sequence":"first","affiliation":[{"name":"Service ICAR Nephrology Department Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Launay\u2010Vacher","sequence":"additional","affiliation":[{"name":"Service ICAR Nephrology Department Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)06154-1"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.23.2823"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000189167"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(75)91684-0"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000180813"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1014489911153"},{"key":"e_1_2_11_8_1","first-page":"253","article-title":"Chronic kidney disease and cancer: a troubling connection","volume":"23","author":"Stengel B","year":"2010","journal-title":"J Nephrol"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-009-0678-8"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-999-0023-5"},{"key":"e_1_2_11_11_1","first-page":"33","article-title":"Changes in the large intestine in patients with chronic kidney failure","volume":"68","author":"Ryss ES","year":"1996","journal-title":"Ter Arkh"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000017575.50319.77"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(86)80148-2"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0091270009347868"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(82)90177-0"},{"key":"e_1_2_11_16_1","first-page":"597","article-title":"[Pharmacokinetic changes in renal failure]","volume":"30","author":"Launay\u2010Vacher V","year":"2001","journal-title":"Presse Med"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199732010-00002"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9236(03)00015-8"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9236(03)00056-0"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.2165\/11534330-000000000-00000"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2011.11.011"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.104.000521"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2005.05.010"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2009.08.004"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000092212"},{"key":"e_1_2_11_26_1","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1681\/ASN.V891470","article-title":"The pathologic physiology of chronic Bright's disease. 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