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Therapy with mineralocorticoid receptor antagonists (<jats:styled-content style=\"fixed-case\">MRA<\/jats:styled-content>s) effectively reduces cardiac risk in discrete populations. Blockade of the mineralocorticoid receptor carries the potential to reduce blood pressure and to promote favorable remodeling of cardiac structure. Preliminary observations suggest that <jats:styled-content style=\"fixed-case\">MRA<\/jats:styled-content>s can improve survival in patients with <jats:styled-content style=\"fixed-case\">ESRD<\/jats:styled-content> though their widespread adoption is tempered by concerns about effectiveness in patients who have reduced kidney function and the risks of hyperkalemia. This generates a particular conundrum, as sudden cardiac arrest is the predominant cause of death in patients with advanced <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>. In this review, we highlight the potential cardiovascular benefits and review the evident risks of <jats:styled-content style=\"fixed-case\">MRA<\/jats:styled-content>s in patients with <jats:styled-content style=\"fixed-case\">ESRD<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/sdi.12421","type":"journal-article","created":{"date-parts":[[2015,8,5]],"date-time":"2015-08-05T03:08:58Z","timestamp":1438744138000},"page":"52-61","source":"Crossref","is-referenced-by-count":8,"title":["Clinical Outcomes in Dialysis Patients: Prospects for Improvement with Aldosterone Receptor Antagonists"],"prefix":"10.1111","volume":"29","author":[{"given":"Samantha Dias","family":"Suthar","sequence":"first","affiliation":[{"name":"Division of Nephrology Department of Medicine Duke University School of Medicine Durham North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John P.","family":"Middleton","sequence":"additional","affiliation":[{"name":"Division of Nephrology 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