{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T05:12:06Z","timestamp":1780377126800,"version":"3.54.1"},"reference-count":67,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes And Digestive And Kidney Diseases","doi-asserted-by":"publisher","award":["R34DK102174"],"award-info":[{"award-number":["R34DK102174"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001463","name":"American Society of Nephrology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001463","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Seminars in Dialysis"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Most dialysis patients are vitamin D deficient, including deficiencies in both activated vitamin D (1, 25\u2010dihydroxyvitamin D) and the less active 25\u2010hydroxyvitamin D. These and other abnormalities associated with chronic kidney disease (<jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>), if they remain untreated, lead to secondary hyperparathyroidism and bone changes, such as osteitis fibrosa cystica. Activated vitamin D has been proven to decrease parathyroid hormone (<jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content>) levels in dialysis patients and is currently used for this indication. There are multiple other potential \u201cpleotrophic\u201d effects associated with vitamin D therapy. These include associations with lower all\u2010cause and cardiovascular mortality, lower rates of infections and improved glycemic indexes. Meta\u2010analyses of multiple observational studies have shown activated vitamin D therapy to be associated with improved survival. Observational data also suggest fewer infections and better glucose control. There have been no randomized clinical trials powered to evaluate mortality or other clinical outcomes. Small trials of nutritional vitamin D (ergocalciferol and cholecalciferol) showed increases in 25\u2010hydroxyvitamin D levels without hypercalcemia or hyperphosphatemia, even when given in addition to activated vitamin D therapy. While activated vitamin D therapy is associated with improved outcomes, it also leads to higher fibroblast growth factor 23 (<jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>\u201023) levels, which may be detrimental in dialysis patients. Further research is needed to evaluate whether activated or nutritional vitamin D therapy are beneficial in dialysis patients for outcomes other than secondary hyperparathyroidism.<\/jats:p>","DOI":"10.1111\/sdi.12446","type":"journal-article","created":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T05:35:01Z","timestamp":1443677701000},"page":"604-609","source":"Crossref","is-referenced-by-count":15,"title":["Vitamin D and Clinical Outcomes in Dialysis"],"prefix":"10.1111","volume":"28","author":[{"given":"Coral","family":"Parikh","sequence":"first","affiliation":[{"name":"Department of Medicine Albert Einstein College of Medicine\/Montefiore Medical Center Bronx New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Gutgarts","sequence":"additional","affiliation":[{"name":"Department of Medicine Albert Einstein College of Medicine\/Montefiore Medical Center Bronx New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliot","family":"Eisenberg","sequence":"additional","affiliation":[{"name":"Department of Medicine Albert Einstein College of Medicine\/Montefiore Medical Center Bronx New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal L.","family":"Melamed","sequence":"additional","affiliation":[{"name":"Department of Medicine Albert Einstein College of Medicine\/Montefiore Medical Center Bronx New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002451"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-63-4-954"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2012.19"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1306357"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.175.4023.768"},{"key":"e_1_2_14_7_1","first-page":"1251","article-title":"1 Alpha, 25\u2010dihydroxycholecalciferol receptors in intestine. 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