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Although oral base therapy could be a solution for correcting acidosis in <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> patients, it increases their already enormous medication load and sodium intake; this approach is not used commonly. Therefore, we need to rely more on correcting acidosis during the <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> procedure, which is difficult to achieve, in part, because <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> is an intermittent therapy. The currently used fixed dialysate bicarbonate concentrations are associated with pre\u2010<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> acidosis and intra\u2010dialytic alkalosis. We suggest that a decreasing dialysate bicarbonate concentration from an initially high concentration be considered as a means of correcting acidosis with limited intra\u2010dialytic alkalosis. Some evidence, as well as theoretical considerations, supports such an approach.<\/jats:p>","DOI":"10.1111\/sdi.12454","type":"journal-article","created":{"date-parts":[[2015,11,23]],"date-time":"2015-11-23T09:33:05Z","timestamp":1448271185000},"page":"35-38","source":"Crossref","is-referenced-by-count":16,"title":["Correcting Acidosis during Hemodialysis: Current Limitations and a Potential Solution"],"prefix":"10.1111","volume":"29","author":[{"given":"David","family":"Tovbin","sequence":"first","affiliation":[{"name":"Department of Nephrology Ha\u2010Emek Medical Center Afula Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard A.","family":"Sherman","sequence":"additional","affiliation":[{"name":"Nephrology Division Department of Medicine Rutgers\u2010 Robert Wood Johnson Medical School New Brunswick New 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